3031654-46-0
Chemical Structure
NC-III-49-1
- CAS 番号: 3031654-46-0
- Formula:C44H50N4O11S2
- Molecular Weight:875.02
IUPAC Name: N,N'-(((((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(3-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-4,1-phenylene))diethanesulfonamide
InChIKey: VGOFJMULWAVDMV-UHFFFAOYSA-N
SMILES: CCS(=O)(NC1=CC=C(C(C(C2=C3C=CC=C2)=CN(C3=O)C)=C1)OCCOCCOCCOCCOC4=CC=C(C=C4C(C5=C6C=CC=C5)=CN(C6=O)C)NS(CC)(=O)=O)=O
Biological Activity: NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc[1].
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NC-III-49-1 | NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc. | |||||||||||||||||||||
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