2. Apoptosis Autophagy
  3. c-Myc Autophagy
  4. KSI-3716

KSI-3716 

Cat. No.: HY-12703 Purity: 99.76%
COA Handling Instructions

KSI-3716 is a potent c-Myc inhibitor that blocks c-MYC/MAX binding to target gene promoters. KSI-3716 is an effective intravesical chemotherapy agent for bladder cancer.

For research use only. We do not sell to patients.

KSI-3716 Chemical Structure

KSI-3716 Chemical Structure

CAS No. : 1151813-61-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 328 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 328 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 550 In-stock
25 mg USD 990 In-stock
50 mg USD 1650 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of KSI-3716:

KSI-3716 Related Antibodies

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  • Biological Activity

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Description

KSI-3716 is a potent c-Myc inhibitor that blocks c-MYC/MAX binding to target gene promoters. KSI-3716 is an effective intravesical chemotherapy agent for bladder cancer[1].

IC50 & Target

c-Myc[1]
In Vitro

KSI-3716 blocks c-MYC/MAX from forming a complex with target gene promoters. KSI-3716 effectively blocks complex formation in a dose dependent manner (IC50=0.84 μM). c-MYC mediated transcriptional activity is inhibited by KSI-3716 at concentrations as low as 1 μM. The expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, is markedly decreased. KSI-3716 exerts cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KSI-3716 Related Antibodies
In Vivo

Intravesical instillation of KSI-3716 at a dose of 5 mg/kg significantly suppresses tumor growth with minimal systemic toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

426.09

Appearance

Solid

Formula

C17H11BrCl2N2O2
CAS No.
SMILES

ClC1=CC=C(Br)C(NC(NC2=CC=C(Cl)C=C2)=C3C(C)=O)=C1C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3469 mL 11.7346 mL 23.4692 mL
5 mM 0.4694 mL 2.3469 mL 4.6938 mL
10 mM 0.2347 mL 1.1735 mL 2.3469 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
Cell Assay
[1]

Ku19-19 cells are seeded 1 day before drug treatment and treated with KSI-3716 (5, 10, 15, 20, 25 μM) for (12, 24, 48 hours). Cell survival assays are performed to count viable cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice[1]

[1]The control group is administered solvent and the experimental group (5 tumor bearing mice per group) is administered c-MYC inhibitor KSI-3716 (5 mg/kg) intravesically twice weekly for 3 weeks. Luminescence images are obtained twice weekly[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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KSI-3716 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

KSI-37161151813-61-4KSI3716KSI 3716c-MycAutophagyMycInhibitorinhibitorinhibit

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