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Cat. No.: HY-150259

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MDEG-541

Customer Review

Based on 1 Customer Validation

MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein.
(Pink: MYC-MAX ligand (HY-175964); Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

Purity: 98.68%
Formula: C₃₅H₃₈N₄O₆S₂
Molecular Weight:674.83

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MDEG-541 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein^[1]. (Pink: MYC-MAX ligand (HY-175964); Blue: Cereblon ligand (HY-14658); Black: linker).

All PROTACs Isoforms :

In Vitro

MDEG-541 (10 µM; 3, 12, 24 h) decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein in a time-dependent manner in KP4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HCT116, PSN1 cells
Concentration:

5, 10, 20 µM
Incubation Time:

24 h
Result:

Decreased the expression of MYC in a dose-dependent manner.

Cell Viability Assay^[1]

Cell Line:

HCT116, PSN1 cells
Concentration:

0-50 µM
Incubation Time:

72 h
Result:

Inhibited cell viability with GI₅₀s of 14.3, 10.7 µM for HCT116, PSN1 cells, respectively.

Chemical Information

Appearance Solid
Molecular Weight 674.83
Formula C₃₅H₃₈N₄O₆S₂
Color Light yellow to yellow
SMILES

O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)NCCCCCCCCN(C/4=O)C(SC4=C/C5=CC=C(C(C)C)C=C5)=S
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 116.67 mg/mL (172.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4819 mL

7.4093 mL

14.8185 mL

5 mM

0.2964 mL

1.4819 mL

2.9637 mL

10 mM

0.1482 mL

0.7409 mL

1.4819 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lier S, et al. A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorg Chem. 2022 Feb;119:105505. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4819 mL	7.4093 mL	14.8185 mL	37.0464 mL
	5 mM	0.2964 mL	1.4819 mL	2.9637 mL	7.4093 mL
	10 mM	0.1482 mL	0.7409 mL	1.4819 mL	3.7046 mL
	15 mM	0.0988 mL	0.4940 mL	0.9879 mL	2.4698 mL
	20 mM	0.0741 mL	0.3705 mL	0.7409 mL	1.8523 mL
	25 mM	0.0593 mL	0.2964 mL	0.5927 mL	1.4819 mL
	30 mM	0.0494 mL	0.2470 mL	0.4940 mL	1.2349 mL
	40 mM	0.0370 mL	0.1852 mL	0.3705 mL	0.9262 mL
	50 mM	0.0296 mL	0.1482 mL	0.2964 mL	0.7409 mL
	60 mM	0.0247 mL	0.1235 mL	0.2470 mL	0.6174 mL
	80 mM	0.0185 mL	0.0926 mL	0.1852 mL	0.4631 mL
	100 mM	0.0148 mL	0.0741 mL	0.1482 mL	0.3705 mL

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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MDEG-541

Apoptosis Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Transcription Factor-Targeted Library

Protein-protein Interaction Inhibitor Library

PROTAC Library

Bioactive Compound Library Max

Covalent Screening Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

All PROTACs Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MDEG-541

Apoptosis Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Transcription Factor-Targeted Library

Protein-protein Interaction Inhibitor Library

PROTAC Library

Bioactive Compound Library Max

Covalent Screening Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

All PROTACs Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MDEG-541 Related Classifications

Cat. No.: HY-150259