1. PROTAC Apoptosis
  2. PROTACs c-Myc
  3. MDEG-541

MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein.

For research use only. We do not sell to patients.

MDEG-541 Chemical Structure

MDEG-541 Chemical Structure

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Description

MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein[1].

In Vitro

MDEG-541 (10 µM; 3, 12, 24 h) decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein in a time-dependent manner in KP4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HCT116, PSN1 cells
Concentration: 5, 10, 20 µM
Incubation Time: 24 h
Result: Decreased the expression of MYC in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: HCT116, PSN1 cells
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Inhibited cell viability with GI50s of 14.3, 10.7 µM for HCT116, PSN1 cells, respectively.
Molecular Weight

674.83

Formula

C35H38N4O6S2

SMILES

O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)NCCCCCCCCN(C/4=O)C(SC4=C/C5=CC=C(C(C)C)C=C5)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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MDEG-541 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MDEG-541
Cat. No.:
HY-150259
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