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Annexin A5/ANXA5 Protein, Mouse (His, Myc)

Cat. No.: HY-P702573
COA Handling Instructions

The annexin A5 (ANXA5) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex, which is critical in the coagulation cascade. As a monomer, ANXA5 plays a key role in regulating the coagulation pathway, affecting the delicate balance between pro- and anti-coagulant factors. Annexin A5/ANXA5 Protein, Mouse (His, Myc) is the recombinant mouse-derived Annexin A5/ANXA5 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Annexin A5/ANXA5 Protein, Mouse (His, Myc) is 318 a.a., with molecular weight of 43.2 kDa.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
20 μg $180 In-stock
50 μg $340 In-stock
100 μg $540 In-stock
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  • Biological Activity

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Description

The annexin A5 (ANXA5) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex, which is critical in the coagulation cascade. As a monomer, ANXA5 plays a key role in regulating the coagulation pathway, affecting the delicate balance between pro- and anti-coagulant factors. Annexin A5/ANXA5 Protein, Mouse (His, Myc) is the recombinant mouse-derived Annexin A5/ANXA5 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Annexin A5/ANXA5 Protein, Mouse (His, Myc) is 318 a.a., with molecular weight of 43.2 kDa.

Background

Annexin A5 (ANXA5) protein serves as an anticoagulant, acting as an indirect inhibitor of the thromboplastin-specific complex crucial in the blood coagulation cascade. Structurally, it exists as a monomer, and in its functional capacity, ANXA5 plays a pivotal role in regulating key components of the coagulation pathway, thereby influencing the delicate balance between procoagulant and anticoagulant factors. Additionally, ANXA5 exhibits binding interactions with ATRX and EIF5B, suggesting its involvement in diverse cellular processes beyond its role in coagulation. These multifaceted attributes underscore the significance of ANXA5 in cellular regulation and its potential implications in both hemostasis and broader cellular functions.

Species

Mouse

Source

E. coli

Tag

N-10*His;C-Myc

Accession

P48036 (A2-D319)

Gene ID

11747

Molecular Construction
N-term
10*His
ANXA5 (A2-D319)
Accession # P48036
Myc
C-term
Synonyms
ANXA5; Annexin A5
Molecular Weight

43.2 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Annexin A5/ANXA5 Protein, Mouse (His, Myc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Annexin A5/ANXA5 Protein, Mouse (His, Myc)
Cat. No.:
HY-P702573
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