2. Apoptosis
  3. c-Myc
  4. IRES-C11

IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes.

For research use only. We do not sell to patients.

IRES-C11 Chemical Structure

IRES-C11 Chemical Structure

CAS No. : 342416-30-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

IRES-C11 Related Antibodies

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Description

IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes[1][2].

In Vitro

IRES-C11 blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-glioblastoma properties when combined with the mechanistic target of mTOR PP242[1].
IRES-C11 (50 nM) significantly inhibits both cyclin D1 and c-MYC IRES activity. IRES-C11 treatment induces a significant shift in both cyclin D1 and c-MYC mRNA to monosomal/nonribosomal fractions, whereas actin mRNA distribution is unaffected. IRES-C11 inhibits both cyclin D1 and c-MYC IRES-mediated mRNA translation, leading to reductions in protein levels.
Mechanistic studies with IRES-C11 reveal binding of the inhibitors within the UP1 fragment of heterogeneous nuclear ribonucleoprotein A1.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRES-C11 Related Antibodies
Molecular Weight

316.14

Formula

C13H11Cl2NO4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(Cl)=C1Cl)N(CC2=CC=C(OC)C=C2OC)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (790.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1632 mL 15.8158 mL 31.6316 mL
5 mM 0.6326 mL 3.1632 mL 6.3263 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1632 mL 15.8158 mL 31.6316 mL 79.0789 mL
5 mM 0.6326 mL 3.1632 mL 6.3263 mL 15.8158 mL
10 mM 0.3163 mL 1.5816 mL 3.1632 mL 7.9079 mL
15 mM 0.2109 mL 1.0544 mL 2.1088 mL 5.2719 mL
20 mM 0.1582 mL 0.7908 mL 1.5816 mL 3.9539 mL
25 mM 0.1265 mL 0.6326 mL 1.2653 mL 3.1632 mL
30 mM 0.1054 mL 0.5272 mL 1.0544 mL 2.6360 mL
40 mM 0.0791 mL 0.3954 mL 0.7908 mL 1.9770 mL
50 mM 0.0633 mL 0.3163 mL 0.6326 mL 1.5816 mL
60 mM 0.0527 mL 0.2636 mL 0.5272 mL 1.3180 mL
80 mM 0.0395 mL 0.1977 mL 0.3954 mL 0.9885 mL
100 mM 0.0316 mL 0.1582 mL 0.3163 mL 0.7908 mL
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IRES-C11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRES-C11342416-30-2c-MycMycIREScyclin-D1heterogeneousnuclearribonucleoproteinA1Inhibitorinhibitorinhibit

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