FUBP1-IN-2
Based on 1 Customer Validation
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines.
For research use only. We do not sell to patients.
- Purity: 99.26%
- CAS No.: 1242862-71-0
- Formula: C26H26ClN3O4
- Molecular Weight:479.96
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
>40 μM
Compound: 9; 0754479
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Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
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[PMID: 36382923] |
| CHO-K1 | EC50 |
8 μM
Compound: 9; 0754479
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Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
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[PMID: 36382923] |
| L3.6pl | IC50 |
16.8 μM
Compound: 9; 0754479
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Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
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[PMID: 36382923] |
FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1242862-71-0
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Appearance Solid
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Molecular Weight 479.96
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Formula C26H26ClN3O4
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Color Off-white to light yellow
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SMILES
COC1=CC=C(C=C1)C(NC2=C(C=C(C=C2)N3CCN(CC3)C4=C(C=CC(Cl)=C4)C)C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 116.67 mg/mL (243.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0835 mL | 10.4175 mL | 20.8351 mL | 52.0877 mL |
| 5 mM | 0.4167 mL | 2.0835 mL | 4.1670 mL | 10.4175 mL | |
| 10 mM | 0.2084 mL | 1.0418 mL | 2.0835 mL | 5.2088 mL | |
| 15 mM | 0.1389 mL | 0.6945 mL | 1.3890 mL | 3.4725 mL | |
| 20 mM | 0.1042 mL | 0.5209 mL | 1.0418 mL | 2.6044 mL | |
| 25 mM | 0.0833 mL | 0.4167 mL | 0.8334 mL | 2.0835 mL | |
| 30 mM | 0.0695 mL | 0.3473 mL | 0.6945 mL | 1.7363 mL | |
| 40 mM | 0.0521 mL | 0.2604 mL | 0.5209 mL | 1.3022 mL | |
| 50 mM | 0.0417 mL | 0.2084 mL | 0.4167 mL | 1.0418 mL | |
| 60 mM | 0.0347 mL | 0.1736 mL | 0.3473 mL | 0.8681 mL | |
| 80 mM | 0.0260 mL | 0.1302 mL | 0.2604 mL | 0.6511 mL | |
| 100 mM | 0.0208 mL | 0.1042 mL | 0.2084 mL | 0.5209 mL |
FUBP1-IN-2 Related Classifications
HY-151884 Related Classifications
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