2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. c-Myc PARP Apoptosis
  4. VPC-70063

VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer.

For research use only. We do not sell to patients.

VPC-70063 Chemical Structure

VPC-70063 Chemical Structure

CAS No. : 13571-44-3

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VPC-70063 Related Antibodies

Top Publications Citing Use of Products

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer[1].

IC50 & Target

IC50: 8.9 μM (Myc-Max)[1]
In Vitro

VPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%[1].
VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP[1].
VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VPC-70063 Related Antibodies

Western Blot Analysis[1]

Cell Line: LNCaP cells
Concentration: 6.25 μM, 12.5 μM and 25 μM
Incubation Time: 48 h
Result: Induced PARP cleavage.
Molecular Weight

378.34

Formula

C16H12F6N2S
CAS No.
SMILES

FC(F)(C1=CC(NC(NCC2=CC=CC=C2)=S)=CC(C(F)(F)F)=C1)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VPC-70063 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VPC-7006313571-44-3VPC70063VPC 70063c-MycPARPApoptosisMycpoly ADP ribose polymerase AnticancerAR-V7UBE2CMyc-MaxLNCaPInhibitorinhibitorinhibit

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