GSTP1 Protein, Cricetulus longicaudatus (sf9, His-Myc)

GSTP1, a key protein, aids in cellular detoxification by conjugating reduced glutathione to hydrophobic electrophiles. It also forms glutathione conjugates for PGA2 and PGJ2 and contributes to hepoxilin synthesis. Additionally, GSTP1 regulates CDK5 activity, preventing neurodegeneration. This versatile enzyme safeguards cellular homeostasis and plays a crucial role in various biochemical pathways. GSTP1 Protein, Cricetulus longicaudatus (sf9, His-Myc) is the recombinant GSTP1 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag.

GSTP1, a pivotal player in cellular detoxification processes, facilitates the conjugation of reduced glutathione to a diverse array of hydrophobic electrophiles, both of exogenous and endogenous origin. This enzymatic activity extends to the formation of glutathione conjugates for prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2), as well as contributing to the synthesis of unique hepoxilin regioisomers. Beyond its role in xenobiotic metabolism, GSTP1 exhibits regulatory functions by negatively modulating CDK5 activity, preventing neurodegeneration by impeding the translocation of p25/p35 to CDK5. This multifaceted enzyme serves as a critical guardian of cellular homeostasis, participating in diverse biochemical pathways with implications for cellular health and response to various physiological challenges.

Others

Sf9 insect cells

N-10*His;C-Myc

P46424 (M1-Q210)

100689311  [NCBI]

Full Length

MPPYTIVYFPVRGRCEAMRILLADQGQSWKEEVVTVETWRKGSLKSTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKDQREAALVDMVNDGVEDLRCKYITLIYTKYEEGKDDYVKALPGHLKPFETLLSQNQGGKAFIVGDQISFVDYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPDHVNRPINGNGKQ

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. /biology-dictionary/c2bbe1-cell.html