PITHD1 Protein, Human (Myc, His)

The PITHD1 protein is a key regulator of cell dynamics, specifically promoting megakaryocyte differentiation by upregulating RUNX1 expression. It does this by activating the proximal promoter of the RUNX1 gene and enhancing the translational activity of the internal ribosome entry site (IRES) element. PITHD1 Protein, Human (Myc, His) is the recombinant human-derived PITHD1 protein, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of PITHD1 Protein, Human (Myc, His) is 211 a.a., with molecular weight of ~31.6 kDa.

PITHD1 Protein emerges as a pivotal regulator in cellular dynamics, specifically promoting megakaryocyte differentiation by up-regulating the expression of RUNX1. Its regulatory influence extends to the modulation of RUNX1 expression, achieved through activation of the proximal promoter of the RUNX1 gene and enhancement of the translation activity of an internal ribosome entry site (IRES) element within the RUNX1 gene. The intricate interplay of PITHD1 in these processes highlights its crucial role in orchestrating megakaryocyte differentiation, underscoring its significance in hematopoiesis. Further exploration of the detailed mechanisms behind PITHD1's regulatory functions offers promising insights into its broader impact on cellular differentiation pathways.

Human

E. coli

N-His;C-Myc

Q9GZP4 (1M-211S)

57095  [NCBI]

MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGIIIMGEDDDSHPSEMRLYKNIPQMSFDDTEREPDQTFSLNRDLTGELEYATKISRFSNVYHLSIHISKNFGADTTKVFYIGLRGEWTELRRHEVTICNYEASANPADHRVHQVTPQTHFIS

Approximately 31.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.