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TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc)

Cat. No.: HY-P700467
Handling Instructions

TPBG/5T4 protein blocks Wnt3a-dependent LRP6 internalization by indirectly interacting with LRP6, thereby potentially inhibiting Wnt/β-catenin signaling. This unique mechanism suggests that TPBG/5T4 plays a crucial role in regulating the Wnt/β-catenin pathway by disrupting LRP6 internalization and affecting downstream signaling. TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc) is the recombinant cynomolgus-derived TPBG/5T4 protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag. The total length of TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc) is 321 a.a., with molecular weight of 39.9 kDa.

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Description

TPBG/5T4 protein blocks Wnt3a-dependent LRP6 internalization by indirectly interacting with LRP6, thereby potentially inhibiting Wnt/β-catenin signaling. This unique mechanism suggests that TPBG/5T4 plays a crucial role in regulating the Wnt/β-catenin pathway by disrupting LRP6 internalization and affecting downstream signaling. TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc) is the recombinant cynomolgus-derived TPBG/5T4 protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag. The total length of TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc) is 321 a.a., with molecular weight of 39.9 kDa.

Background

The TPBG/5T4 Protein emerges as a potential inhibitor of Wnt/beta-catenin signaling, operating through an indirect interaction with LRP6 and the blocking of Wnt3a-dependent LRP6 internalization. This distinctive mechanism suggests that TPBG/5T4 plays a crucial role in regulating the Wnt/beta-catenin pathway by disrupting the internalization process of LRP6, thereby influencing downstream signaling events. This insight into TPBG/5T4's function underscores its significance in modulating the intricate molecular dynamics associated with Wnt/beta-catenin signaling, offering a potential avenue for therapeutic exploration in the context of cellular regulatory processes.

Species

Cynomolgus

Source

HEK293

Tag

C-Myc;N-10*His

Accession

Q4R8Y9 (T35-S355)

Gene ID

102132149  [NCBI]

Molecular Construction
N-term
10*His
TLR8 (T35-S355)
Accession # Q4R8Y9
Myc
C-term
Synonyms
rCynTrophoblast glycoprotein/5T4, His; TPBG; 5T4 Protein, Human; 5T4AG Protein, Human; M6P1 Protein, Human; WAIF1 Protein, Human
AA Sequence

TSSASSSSSSAPFLASAASAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPLYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRGGAFEHLPSLRQLDLSHNPLAYLSPFAFSGSNASISAPSPLVELILNHIVPPDDKRQNRSFEGMVAAALVAGRALQGLHLLELASNHFLYLPRDVLAQLPSLRYLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHVRVFLDNNPWVCDCHMADMVTWLKQTGVVQGKDRLTCAFPEKMRNRVLLELNSADLDCDPILPPSLQTS

Molecular Weight

39.9 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc)
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HY-P700467
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