2. Epigenetics
  3. Epigenetic Reader Domain
  4. BET-IN-19

BET-IN-19 (Compound 146) is a BET inhibitor. BET-IN-19 inhibits hlL-6 mRNA transcription (IC50 ≤ 0.3 uM), and c-myc activity in human AML MV4-11 cell (IC50 ≤ 0.3 uM)。BET-IN-19 inhibits tetra-acetylated histone H4 binding to BRD4 bromodomain 1 (IC50 ≤ 0.3 uM).

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BET-IN-19 Chemical Structure

BET-IN-19 Chemical Structure

CAS No. : 1643947-30-1

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BET-IN-19 Related Antibodies

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Description

BET-IN-19 (Compound 146) is a BET inhibitor. BET-IN-19 inhibits hlL-6 mRNA transcription (IC50 ≤ 0.3 uM), and c-myc activity in human AML MV4-11 cell (IC50 ≤ 0.3 uM)。BET-IN-19 inhibits tetra-acetylated histone H4 binding to BRD4 bromodomain 1 (IC50 ≤ 0.3 uM)[1].

Molecular Weight

333.39

Formula

C19H19N5O
CAS No.
SMILES

CNC1=NC(N=CC(C2=C(C)ON=C2C)=C3)=C3N1CC4=CC=CC=C4
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Purity & Documentation
References
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BET-IN-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BET-IN-191643947-30-1Epigenetic Reader DomainhlL-6c-mycAML MV4-11BRD4Inhibitorinhibitorinhibit

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