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  5. CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc)

CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc)

Cat. No.: HY-P700433
Handling Instructions

CD30/TNFRSF8, a receptor for TNFSF8/CD30L, regulates cellular growth and lymphoblast transformation. It activates NF-kappa-B, modulating gene expression. Interactions with TRAF1, TRAF2, TRAF3, and TRAF5 indicate involvement in complex signaling networks. Engagement with TNFSF8 implies impact on immune responses and cellular homeostasis, emphasizing its significance in fundamental biological processes. CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc) is the recombinant human-derived CD30/TNFRSF8 protein, expressed by HEK293, with C-Myc, N-10*His labeled tag. The total length of CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc) is 361 a.a., with molecular weight of 43.5 kDa.

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Description

CD30/TNFRSF8, a receptor for TNFSF8/CD30L, regulates cellular growth and lymphoblast transformation. It activates NF-kappa-B, modulating gene expression. Interactions with TRAF1, TRAF2, TRAF3, and TRAF5 indicate involvement in complex signaling networks. Engagement with TNFSF8 implies impact on immune responses and cellular homeostasis, emphasizing its significance in fundamental biological processes. CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc) is the recombinant human-derived CD30/TNFRSF8 protein, expressed by HEK293, with C-Myc, N-10*His labeled tag. The total length of CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc) is 361 a.a., with molecular weight of 43.5 kDa.

Background

CD30/TNFRSF8, a receptor for TNFSF8/CD30L, is implicated in the regulation of cellular growth and the transformation of activated lymphoblasts. This receptor plays a role in modulating gene expression by activating NF-kappa-B, a key transcription factor associated with diverse cellular processes. The interaction of CD30/TNFRSF8 with signaling adapters such as TRAF1, TRAF2, TRAF3, and TRAF5 underscores its involvement in intricate cellular signaling networks. This receptor's engagement with TNFSF8 suggests its potential impact on immune responses and cellular homeostasis, highlighting its significance in the regulation of fundamental biological processes.

Species

Human

Source

HEK293

Tag

C-Myc;N-10*His

Accession

P28908 (F19-K379)

Gene ID

943  [NCBI]

Molecular Construction
N-term
10*His-Myc
CD30 (F19-K379)
Accession # P28908
C-term
Synonyms
rHuTumor necrosis factor receptor superfamily member 8/CD30, His; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8
AA Sequence

FPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGK

Molecular Weight

43.5 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc)
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HY-P700433
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