BIN1 Protein, Human (His)

The BIN1 protein is essential for controlling plasma membrane curvature and shape and is essential for the formation of T-tubules in muscle cells. It acts as a negative regulator of endocytosis and affects intracellular vesicle sorting. BIN1 Protein, Human (His) is the recombinant human-derived BIN1 protein, expressed by E. coli , with N-His labeled tag. The total length of BIN1 Protein, Human (His) is 424 a.a., with molecular weight of ~52 kDa.

The BIN1 Protein plays a crucial role in the regulation of plasma membrane curvature, shaping, and remodeling. In muscle cells, it is indispensable for the formation of T-tubules, which are tubular invaginations of the plasma membrane critical for depolarization-contraction coupling. Acting as a negative regulator of endocytosis, BIN1 is also involved in intracellular vesicle sorting and modulates BACE1 trafficking, influencing amyloid-beta production. In neuronal circuits, its role in endocytosis regulation may impact the internalization of PHF-tau aggregates. Furthermore, BIN1 is implicated in the regulation of MYC activity, influencing cell proliferation, and exhibits actin bundling activity, stabilizing actin filaments against depolymerization. BIN1 forms a heterodimer with AMPH, binds to SH3GLB1, interacts with DNM1, SYNJ1, DNM2, AP2A2, AP2B1, MYC, BIN2, SNX4, and BACE1, indicating its involvement in diverse cellular processes and protein-protein interactions.

Human

E. coli

N-His

O00499-10 (M1-P424)

274  [NCBI]

Approximately 52 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.