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Annexin A4/ANXA4 Protein, Mouse (His-Myc)

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The Annexin A4/ANXA4 protein is a calcium/phospholipid-binding protein that plays a key role in membrane dynamics by promoting membrane fusion and exocytosis. This protein exhibits specific affinity for calcium ions and phospholipids, allowing it to participate in cellular processes involving membrane interactions. Annexin A4/ANXA4 Protein, Mouse (His-Myc) is the recombinant mouse-derived Annexin A4/ANXA4 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: E. coli
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
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Biological Activity

Description

The Annexin A4/ANXA4 protein is a calcium/phospholipid-binding protein that plays a key role in membrane dynamics by promoting membrane fusion and exocytosis. This protein exhibits specific affinity for calcium ions and phospholipids, allowing it to participate in cellular processes involving membrane interactions. Annexin A4/ANXA4 Protein, Mouse (His-Myc) is the recombinant mouse-derived Annexin A4/ANXA4 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

Background

Annexin A4 (ANXA4) is a calcium/phospholipid-binding protein known for its crucial role in membrane fusion and participation in exocytosis. Functioning as a mediator between calcium signaling and membrane dynamics, ANXA4 contributes to cellular processes involved in the release of cellular contents. Its ability to bind to both calcium ions and phospholipids suggests a regulatory role in membrane-related events, particularly those associated with vesicle trafficking and exocytosis. It has to highlight ANXA4's significance in calcium-dependent cellular mechanisms, emphasizing its involvement in promoting membrane fusion and facilitating exocytotic processes.

Technical Parameters

  • Species Mouse
  • Source E. coli
  • Tag N-10*His;C-Myc
  • Accession

    P97429 (E2-D319)

  • Gene ID
    11746  [NCBI]
  • Molecular Construction
    • N-term
    • 10*His
    • ANXA4 (E2-D319)
      Accession # P97429
    • Myc
    • C-term
  • Protein Length

    Full Length

  • Synonyms

    ANXA4; P32.5; Prev. ANX4; Annexin IV (Placental Anticoagulant Protein II); Carbohydrate-Binding Protein P33/P41; Epididymis Secretory Protein Li 274; Placental Anticoagulant Protein II; Proliferation-Inducing Protein 28; 35-Beta Calcimedin; Proliferation-

  • AA Sequence

    EAKGGTVKAASGFNATEDAQTLRKAMKGLGTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSELSSNFEQVILGLMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSLSAAGRDEGNYLDDALMKQDAQELYEAGEKRWGTDEVKFLSILCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRSKPSYFAERLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRASFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDD

  • Predicted Molecular Mass

    40.8 kDa

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HC1, 0.5 M NaCl, 6% trehalose, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US;may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Annexin A4/ANXA4 Protein, Mouse (His-Myc) Product Image