HNRNPA2B1 Protein, Mouse (His-SUMO, Myc)

HNRNPA2B1 Protein, a heterogeneous nuclear ribonucleoprotein (hnRNP), plays a pivotal role in RNA processing and transport. It associates with nascent pre-mRNAs, participating in the formation of hnRNP particles that condense and stabilize transcripts, minimizing tangling and knotting. This packaging process influences various cellular functions, including transcription, pre-mRNA processing, RNA nuclear export, subcellular localization, mRNA translation, and the stability of mature mRNAs. HNRNPA2B1 forms hnRNP particles with multiple hnRNPs and heterogeneous nuclear RNAs in the nucleus. Notably, in oligodendrocytes and neurons, it facilitates the transport of specific mRNAs to the cytoplasm by recognizing and binding A2RE or A2RE11 sequence motifs on select mRNAs. Beyond mRNA transport, HNRNPA2B1 also binds telomeric DNA sequences, protecting them from endonuclease digestion, and acts as a 'reader' of the N6-methyladenosine (m6A) mark on pri-miRNAs, promoting pri-miRNA processing and miRNA sorting into exosomes. Additionally, it serves as a regulator of mRNA splicing, impacting the splicing of genes like pyruvate kinase PKM. Furthermore, HNRNPA2B1 is implicated in the activation of the innate immune response, sensing viral DNA, and translocating to the cytoplasm to activate the TBK1-IRF3 pathway. These diverse functions highlight the versatility of HNRNPA2B1 in cellular processes.