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Cat. No.: HY-146445

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P300 bromodomain-IN-1

P300 bromodomain-IN-1 (Compoun 1u) is a potent p300 (EP300) bromodomain inhibitor with an IC₅₀ of 49 nM. P300 bromodomain-IN-1 suppresses the expression of c-Myc and induces G1/G0 phase arrest and apoptosis in OPM-2 cells.

For research use only. We do not sell to patients.

Formula: C₂₉H₃₁ClN₄O₄
Molecular Weight:535.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

P300 bromodomain-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

p300

49 nM (IC₅₀)

All Epigenetic Reader Domain Isoforms :

All Histone Acetyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	3.74 μM Compound: 1u	Antiproliferative activity against human 22Rv1 cells incubated for 5 days by CCK-8 method Antiproliferative activity against human 22Rv1 cells incubated for 5 days by CCK-8 method	[PMID: 35569250]
MCF7	IC₅₀	0.96 μM Compound: 1u	Antiproliferative activity against human MCF7 cells incubated for 5 days by CCK-8 method Antiproliferative activity against human MCF7 cells incubated for 5 days by CCK-8 method	[PMID: 35569250]
OPM-2	IC₅₀	1.09 μM Compound: 1u	Antiproliferative activity against human OPM-2 cells incubated for 5 days by CCK-8 method Antiproliferative activity against human OPM-2 cells incubated for 5 days by CCK-8 method	[PMID: 35569250]
SCC-9	IC₅₀	1.85 μM Compound: 1u	Antiproliferative activity against human SCC-9 cells incubated for 5 days by CCK-8 method Antiproliferative activity against human SCC-9 cells incubated for 5 days by CCK-8 method	[PMID: 35569250]

Chemical Information

Molecular Weight 535.03
Formula C₂₉H₃₁ClN₄O₄
SMILES

COC1=CC=C(C=C1Cl)N2C(C[C@H]2C3=NC4=CC(C5=C(ON=C5C)C)=CC=C4N3[C@H]6CC[C@@H](CC6)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Z, et al. Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells. Bioorg Med Chem. 2022 Jul 15;66:116784. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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P300 bromodomain-IN-1

All Epigenetic Reader Domain Isoforms

All Histone Acetyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

P300 bromodomain-IN-1 Related Classifications

HY-146445 Related Classifications