1. Apoptosis
  2. c-Myc
  3. 10074-A4

10074-A4 

Cat. No.: HY-124129
Handling Instructions

10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects.

For research use only. We do not sell to patients.

10074-A4 Chemical Structure

10074-A4 Chemical Structure

CAS No. : 312631-87-1

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Description

10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].

In Vitro

10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1 μM[1].
10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4[1].
10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ‘ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HL-60 cells
Concentration: 25 μM, 50 μM
Incubation Time: 24 hours
Result: Arrested the cell cycle at the S-phase.
Molecular Weight

409.29

Formula

C₁₈H₁₄Cl₂N₂O₃S

CAS No.
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10074-A4
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