1. Metabolic Enzyme/Protease
  2. Hexokinase

Lonidamine (Synonyms: DICA; Diclondazolic Acid; AF1890)

Cat. No.: HY-B0486 Purity: 95.45%
Handling Instructions

Lonidamine is an orally administered small molecule hexokinase inactivator.

For research use only. We do not sell to patients.

Lonidamine Chemical Structure

Lonidamine Chemical Structure

CAS No. : 50264-69-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Lonidamine is an orally administered small molecule hexokinase inactivator. Target: Others Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP. Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours. From Wikipedia.

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1137 mL 15.5686 mL 31.1371 mL
5 mM 0.6227 mL 3.1137 mL 6.2274 mL
10 mM 0.3114 mL 1.5569 mL 3.1137 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

321.16

Formula

C₁₅H₁₀Cl₂N₂O₂

CAS No.

50264-69-2

SMILES

O=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Lonidamine
Cat. No.:
HY-B0486
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Lonidamine

Cat. No.: HY-B0486