1. Metabolic Enzyme/Protease
  2. Hexokinase
    Mitochondrial Metabolism
  3. Lonidamine

Lonidamine (Synonyms: DICA; Diclondazolic Acid; AF1890)

Cat. No.: HY-B0486 Purity: 95.45%
Handling Instructions

Lonidamine, a antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II[1][2].

For research use only. We do not sell to patients.

Lonidamine Chemical Structure

Lonidamine Chemical Structure

CAS No. : 50264-69-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Lonidamine, a antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II[1][2].

IC50 & Target

Ki: 2.5 μM (Mitochondrial pyruvate carrier)[2]

Clinical Trial
Molecular Weight

321.16

Formula

C₁₅H₁₀Cl₂N₂O₂

CAS No.

50264-69-2

SMILES

O=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (155.69 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1137 mL 15.5686 mL 31.1371 mL
5 mM 0.6227 mL 3.1137 mL 6.2274 mL
10 mM 0.3114 mL 1.5569 mL 3.1137 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Lonidamine
Cat. No.:
HY-B0486
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