1. Metabolic Enzyme/Protease
    Apoptosis
  2. Hexokinase
    Mitochondrial Metabolism
    Apoptosis
  3. Lonidamine

Lonidamine (Synonyms: AF-1890; Diclondazolic Acid; DICA)

Cat. No.: HY-B0486 Purity: 97.08%
Handling Instructions

Lonidamine (AF-1890), an antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II.

For research use only. We do not sell to patients.

Lonidamine Chemical Structure

Lonidamine Chemical Structure

CAS No. : 50264-69-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Lonidamine (AF-1890), an antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II[1][2].

IC50 & Target

Ki: 2.5 μM (Mitochondrial pyruvate carrier)[2]

Clinical Trial
Molecular Weight

321.16

Formula

C₁₅H₁₀Cl₂N₂O₂

CAS No.

50264-69-2

SMILES

O=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (155.69 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1137 mL 15.5686 mL 31.1371 mL
5 mM 0.6227 mL 3.1137 mL 6.2274 mL
10 mM 0.3114 mL 1.5569 mL 3.1137 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LonidamineAF-1890Diclondazolic AcidDICAAF1890AF 1890HexokinaseMitochondrial MetabolismApoptosisInhibitorinhibitorinhibit

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Product Name:
Lonidamine
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HY-B0486
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