1. Metabolic Enzyme/Protease
    Apoptosis
    Autophagy
  2. Hexokinase
    Apoptosis
    Autophagy
  3. 3-Bromopyruvic acid

3-Bromopyruvic acid (Synonyms: Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP)

Cat. No.: HY-19992 Purity: ≥98.0%
Handling Instructions

3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities.

For research use only. We do not sell to patients.

3-Bromopyruvic acid Chemical Structure

3-Bromopyruvic acid Chemical Structure

CAS No. : 1113-59-3

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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities[1][2][3].

In Vitro

3-Bromopyruvate enhances TRAIL-induced apoptosis in breast cancer cells[2].
3-Bromopyruvate (Bromopyruvic acid), a hexokinase II inhibitor, can induce apoptosis in hepatocellular carcinoma cells by inducing endoplasmic reticulum (ER) stress[2].
3-Bromopyruvate inhibits ATP generation and upregulates the expression of DR5. 3-Bromopyruvate upregulates CHOP, GRP78 and the phosphorylation of AMPK and augments TRAIL-induced Bax and caspase-3 levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 40, 80, 160 or 320 µM
Incubation Time: 24 hours
Result: 3-Bromopyruvate (80 and 160 µmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability.
In Vivo

3-Bromopyruvate (8 mg/kg; i.p.; every 4 days for 28 days) shows a synergistic antitumor effect in MCF-7 cell xenografts in nude mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (BALB/c; 4-5-weeks old and 18-20 g)[2]
Dosage: 8 mg/kg
Administration: I.p.; every 4 days for 28 days
Result: Showed antitumor efficacy in tumor xenografts.
Molecular Weight

166.96

Formula

C₃H₃BrO₃

CAS No.
SMILES

O=C(O)C(CBr)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 32 mg/mL (191.66 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9895 mL 29.9473 mL 59.8946 mL
5 mM 1.1979 mL 5.9895 mL 11.9789 mL
10 mM 0.5989 mL 2.9947 mL 5.9895 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥98.0%

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Keywords:

3-Bromopyruvic acidBromopyruvic acid Hexokinase II Inhibitor II, 3-BPHexokinaseApoptosisAutophagyanaloguepyruvateglycolysisERstressMCF-7MDA-MB-231cellsInhibitorinhibitorinhibit

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3-Bromopyruvic acid
Cat. No.:
HY-19992
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