1. Metabolic Enzyme/Protease
  2. Hexokinase

3-Bromopyruvic acid (Synonyms: Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP)

Cat. No.: HY-19992 Purity: 99.33%
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3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells.

For research use only. We do not sell to patients.
3-Bromopyruvic acid Chemical Structure

3-Bromopyruvic acid Chemical Structure

CAS No. : 1113-59-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 66 In-stock
1 g USD 60 In-stock
5 g USD 72 In-stock
10 g USD 96 In-stock
25 g USD 192 In-stock
50 g   Get quote  

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3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells. Target: hexokinase II in vitro: 3-BrPA dissociates HK II from this complex, causing cell death, and thus, having an anti-tumor effect. In vitro treatment of cells with 3-BrPA significantly inhibited their growth, as evaluated by MTT assay and adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA). [1] 3-Bromopyruvic acid (3-BP) is a glycolytic inhibitor and a promising anticancer compound, induces oxidative stress and depletes cells of glutathione (GSH). [2] in vivo: 3-BrPA treatment (50 mg/kg ip. daily, 6 days/week for three weeks) is effective in the animal model by attenuating tumor growth and causing tumor necrosis. Toxic signs were not observed. The acute toxicity study provided an LD50 of 191.7 mg/kg for 3-BrPA. [1]

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 5.9895 mL 29.9473 mL 59.8946 mL
5 mM 1.1979 mL 5.9895 mL 11.9789 mL
10 mM 0.5989 mL 2.9947 mL 5.9895 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight








Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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