1. Metabolic Enzyme/Protease
  2. Hexokinase

3-Bromopyruvic acid (Synonyms: Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP)

Cat. No.: HY-19992 Purity: 99.33%
Data Sheet SDS Handling Instructions

3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells.

For research use only. We do not sell to patients.
3-Bromopyruvic acid Chemical Structure

3-Bromopyruvic acid Chemical Structure

CAS No. : 1113-59-3

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Description

3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells. Target: hexokinase II in vitro: 3-BrPA dissociates HK II from this complex, causing cell death, and thus, having an anti-tumor effect. In vitro treatment of cells with 3-BrPA significantly inhibited their growth, as evaluated by MTT assay and adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA). [1] 3-Bromopyruvic acid (3-BP) is a glycolytic inhibitor and a promising anticancer compound, induces oxidative stress and depletes cells of glutathione (GSH). [2] in vivo: 3-BrPA treatment (50 mg/kg ip. daily, 6 days/week for three weeks) is effective in the animal model by attenuating tumor growth and causing tumor necrosis. Toxic signs were not observed. The acute toxicity study provided an LD50 of 191.7 mg/kg for 3-BrPA. [1]

References
Molecular Weight

166.96

Formula

C₃H₃BrO₃

CAS No.

1113-59-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
3-Bromopyruvic acid
Cat. No.:
HY-19992
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