1113-59-3
Chemical Structure
3-Bromopyruvic acid
Synonym(s): Bromopyruvic acid; 3-BrPA; Hexokinase II Inhibitor II, 3-BP
- CAS 番号: 1113-59-3
- Formula:C3H3BrO3
- Molecular Weight:166.96
IUPAC Name: 3-bromo-2-oxopropanoic acid
InChIKey: PRRZDZJYSJLDBS-UHFFFAOYSA-N
SMILES: O=C(O)C(CBr)=O
Biological Activity: 3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities[1][2][3].
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3-Bromopyruvic acid | 98.0% | 3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities. | ||||||||||||||||||||
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- [1]. Gan L, et al. Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy. Onco Targets Ther. 2020;13:11125-11137. Published 2020 Oct 29. [Content Brief]
- [2]. Chen Y, et al. 3 Bromopyruvate sensitizes human breast cancer cells to TRAIL induced apoptosis via the phosphorylated AMPK mediated upregulation of DR5. Oncol Rep. 2018;40(5):2435-2444. [Content Brief]
- [3]. Zhang Q, et al. Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells. Genes Cancer. 2014;5(3-4):100-112. [Content Brief]
Keywords
