1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Hydroxypyruvic acid

Hydroxypyruvic acid (Synonyms: β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid)

Cat. No.: HY-113013
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Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

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Hydroxypyruvic acid Chemical Structure

Hydroxypyruvic acid Chemical Structure

CAS No. : 1113-60-6

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Description

Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Hydroxypyruvic acid (intravenous injection; 100 mg/ml; slowly over 10 min) increases the 5-h urinary oxalate and glycolate excretion to 0.68% (6.56 μmol) and 0.53% (5.10 μmol) in control rats, in addition, it increases to 2.43% (23.36 μmol) and 0.79% (7.59 μmol) of the dose in the vitamin-B6-deficient rats[1].

Animal Model: SD rat[1]
Dosage: 100 mg/ml; slowly over 10 min
Administration: Intravenous injection
Result: Led to a significant increase of urinary oxalate and glycolate excretion in both control and vitamin-B6-deficient rats, but these changes are exaggerated in the vitamin-B6-deficient group.
Molecular Weight

104.06

Formula

C₃H₄O₄

CAS No.

1113-60-6

SMILES

O=C(O)C(CO)=O

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Keywords:

Hydroxypyruvic acidβ-Hydroxypyruvic acid3-Hydroxypyruvic acidEndogenous MetaboliteSubstrateUrinaryoxalateendogenousmetabolicdiorderdimethylglycinedehydrogenasedeficiencyglycineserinethreonineInhibitorinhibitorinhibit

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Hydroxypyruvic acid
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HY-113013
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