2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Hydroxypyruvic acid

Hydroxypyruvic acid  (Synonyms: β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid)

Cat. No.: HY-113013 Purity: ≥98.0%
COA Handling Instructions

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Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

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Hydroxypyruvic acid Chemical Structure

Hydroxypyruvic acid Chemical Structure

CAS No. : 1113-60-6

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1 mg USD 180 In-stock
5 mg USD 540 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Hydroxypyruvic acid:

Hydroxypyruvic acid Related Antibodies

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Description

Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Hydroxypyruvic acid (intravenous injection; 100 mg/ml; slowly over 10 min) increases the 5-h urinary oxalate and glycolate excretion to 0.68% (6.56 μmol) and 0.53% (5.10 μmol) in control rats, in addition, it increases to 2.43% (23.36 μmol) and 0.79% (7.59 μmol) of the dose in the vitamin-B6-deficient rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rat[1]
Dosage: 100 mg/ml; slowly over 10 min
Administration: Intravenous injection
Result: Led to a significant increase of urinary oxalate and glycolate excretion in both control and vitamin-B6-deficient rats, but these changes are exaggerated in the vitamin-B6-deficient group.
Molecular Weight

104.06

Formula

C3H4O4
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(O)C(CO)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 40 mg/mL (384.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.6098 mL 48.0492 mL 96.0984 mL
5 mM 1.9220 mL 9.6098 mL 19.2197 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (244 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.6098 mL 48.0492 mL 96.0984 mL 240.2460 mL
5 mM 1.9220 mL 9.6098 mL 19.2197 mL 48.0492 mL
10 mM 0.9610 mL 4.8049 mL 9.6098 mL 24.0246 mL
15 mM 0.6407 mL 3.2033 mL 6.4066 mL 16.0164 mL
20 mM 0.4805 mL 2.4025 mL 4.8049 mL 12.0123 mL
25 mM 0.3844 mL 1.9220 mL 3.8439 mL 9.6098 mL
30 mM 0.3203 mL 1.6016 mL 3.2033 mL 8.0082 mL
40 mM 0.2402 mL 1.2012 mL 2.4025 mL 6.0062 mL
50 mM 0.1922 mL 0.9610 mL 1.9220 mL 4.8049 mL
60 mM 0.1602 mL 0.8008 mL 1.6016 mL 4.0041 mL
80 mM 0.1201 mL 0.6006 mL 1.2012 mL 3.0031 mL
100 mM 0.0961 mL 0.4805 mL 0.9610 mL 2.4025 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Hydroxypyruvic acid Related Classifications

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Keywords:

Hydroxypyruvic acid1113-60-6β-Hydroxypyruvic acid 3-Hydroxypyruvic acidEndogenous MetaboliteSubstrateUrinaryoxalateendogenousmetabolicdiorderdimethylglycinedehydrogenasedeficiencyglycineserinethreonineInhibitorinhibitorinhibit

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