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oxalate

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50

Inhibitors & Agonists

1

Fluorescent Dye

3

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1

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11

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-A0118A
    Naloxegol oxalate
    2 Publications Verification

    NKTR-118 oxalate; AZ-13337019 oxalate

    Opioid Receptor Neurological Disease
    Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .
    Naloxegol <em>oxalate</em>
  • HY-135810A

    Desethylhydroxychloroquine oxalate

    Influenza Virus Parasite Infection Inflammation/Immunology
    Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment .
    Cletoquine <em>oxalate</em>
  • HY-13410
    Xanomeline oxalate
    1 Publications Verification

    LY246708 oxalate

    mAChR Neurological Disease
    Xanomeline oxalate (LY246708 oxalate) is a potent and selective muscarinic receptor agonist (SMRA) and stimulates phosphoinositide hydrolysis in vivo. Xanomeline oxalate can be used for the research of Alzheimer’s disease .
    Xanomeline <em>oxalate</em>
  • HY-152849A

    HL5101 oxalate

    c-Met/HGFR Cancer
    Boditrectinib oxalate is a potent tyrosine kinase inhibitor. Boditrectinib oxalate serves as an antineoplastic agent. Boditrectinib oxalate is useful in the research of cancer, inflammation, neurodegenerative diseases and certain infectious diseases .
    Boditrectinib <em>oxalate</em>
  • HY-13225

    RJR-2403 oxalate; (E)-Metanicotine oxalate

    nAChR Neurological Disease
    Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).
    Rivanicline <em>oxalate</em>
  • HY-14258AR

    (S)-Citalopram oxalate (Standard); (S)-(+)-Citalopram oxalate (Standard)

    Serotonin Transporter Neurological Disease Cancer
    Escitalopram (oxalate) (Standard) is the analytical standard of Escitalopram (oxalate). This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .
    Escitalopram <em>oxalate</em> (Standard)
  • HY-14258A
    Escitalopram oxalate
    3 Publications Verification

    (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate

    Serotonin Transporter Neurological Disease
    Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .
    Escitalopram <em>oxalate</em>
  • HY-B1107

    Nafronyl oxalate salt

    5-HT Receptor Cardiovascular Disease
    Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.
    Naftidrofuryl <em>oxalate</em>
  • HY-A0118AS

    Isotope-Labeled Compounds Opioid Receptor Neurological Disease
    Naloxegol-d5 (oxalate) is deuterium labeled Naloxegol (oxalate). Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation[1][2].
    Naloxegol-d5 <em>oxalate</em>
  • HY-14258AS1

    (S)-Citalopram-d4 oxalate; (S)-(+)-Citalopram-d4 oxalate

    Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Escitalopram-d4 (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].
    Escitalopram-d4 <em>oxalate</em>
  • HY-121203S1

    Isotope-Labeled Compounds Others
    Citalopram-d6 oxalate is the deuterium labeled Citalopram oxalate .
    Citalopram-d6 <em>oxalate</em>
  • HY-19695
    (-)-p-Bromotetramisole oxalate
    1 Publications Verification

    L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate

    Phosphatase Cancer
    (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
    (-)-p-Bromotetramisole <em>oxalate</em>
  • HY-107759

    UCL-1397 oxalate

    Others Neurological Disease
    Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .
    Butabindide <em>oxalate</em>
  • HY-14258AS

    Serotonin Transporter Neurological Disease
    Escitalopram-d6 (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].
    Escitalopram-d6 <em>oxalate</em>
  • HY-132373S

    Isotope-Labeled Compounds Others
    N-Hydroxy Mexiletine-d6 Oxalate is the deuterium labeled N-Hydroxy Mexiletine Oxalate[1].
    N-Hydroxy Mexiletine-d6 <em>Oxalate</em>
  • HY-143931S

    Isotope-Labeled Compounds Others
    N-Desmethyl citalopram-d4 (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate[1].
    N-Desmethyl citalopram-d4 <em>oxalate</em>
  • HY-107656

    mAChR Neurological Disease
    PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects .
    PTAC <em>oxalate</em>
  • HY-110289S1

    Isotope-Labeled Compounds Others
    (R)-Citalopram-d4 (oxalate) is deuterium labeled (R)-Citalopram Oxalate.
    (R)-Citalopram-d4 <em>oxalate</em>
  • HY-148669B

    (S)-Menin-MLL inhibitor 24 oxalate

    Epigenetic Reader Domain Cancer
    (S)-Bleximenib ((S)-Menin-MLL inhibitor 24) oxalate is a S-Enantiomer of (S)-Menin-MLL inhibitor 24 oxalate (HY-148669A). (S)-Bleximenib oxalate is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer .
    (S)-Bleximenib <em>oxalate</em>
  • HY-110289

    Serotonin Transporter 5-HT Receptor Neurological Disease
    (R)-Citalopram oxalate is an anticonvulsant, antidepressant and muscle relaxant. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (Escitalopram; HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate functionally antagonises S-citalopram in vivo and in vitro. (R)-Citalopram oxalate has an effect on the association of Escitalopram with the high affinity primary site, and on its dissociation from the 5-HT transporter, via an allosteric mechanism .
    (R)-Citalopram <em>oxalate</em>
  • HY-151910S1

    Isotope-Labeled Compounds Others
    (±)-Fluoxetine-dd5 Oxalate (phenyl-dd5) is the deuterium labeled (±)-Fluoxetine Oxalate[1].
    (±)-Fluoxetine-d5 <em>Oxalate</em> (phenyl-d5)
  • HY-12199A

    Tiprolisant oxalate

    Histamine Receptor Neurological Disease Endocrinology
    Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
    Pitolisant <em>oxalate</em>
  • HY-107460

    Ephrin Receptor Cancer
    LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC .
    LDN-211904 <em>oxalate</em>
  • HY-149854A

    Sigma Receptor Neurological Disease
    AB21 oxalate is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 oxalate has the effect of reducing mechanical hypersensitivity .
    AB21 <em>oxalate</em>
  • HY-151910S

    Isotope-Labeled Compounds Others
    (±)-Fluoxetine-d4 Oxalate (trifluoromethylphen-d4-oxy) is the deuterium labeled (±)-Fluoxetine Oxalate[1].
    (±)-Fluoxetine-d4 <em>Oxalate</em> (trifluoromethylphen-d4-oxy)
  • HY-111081C

    Sigma Receptor Neurological Disease
    (±)-PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±)-PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats .
    (±)-PPCC <em>oxalate</em>
  • HY-110366

    SAX-187 oxalate

    5-HT Receptor Neurological Disease
    WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .
    WAY-181187 <em>oxalate</em>
  • HY-19668A

    5-HT Receptor Neurological Disease
    SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses [1]
    SGS518 <em>oxalate</em>
  • HY-107758

    Prolyl Endopeptidase (PREP) Cancer
    Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM) .
    Y-29794 <em>oxalate</em>
  • HY-103098

    5-HT Receptor Neurological Disease
    EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects .
    EMDT <em>oxalate</em>
  • HY-126568S1

    Isotope-Labeled Compounds Others
    Nafronyl-d4 (oxalate) is deuterium labeled Naftidrofuryl.
    Nafronyl-d4 <em>oxalate</em>
  • HY-108512A

    Sigma Receptor Neurological Disease
    PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 oxalate shows potential antipsychotic activity .
    PD 144418 <em>oxalate</em>
  • HY-137966A

    AL-8520 oxalate

    Carbonic Anhydrase Cancer
    N-Desethyl Brinzolamide oxalate is a dual inhibitor of Carbonic anhydrase II and Carbonic anhydrase IV with IC50s of 1.28 and 128 nM, respectively .
    N-Desethyl Brinzolamide <em>oxalate</em>
  • HY-W127854

    Biochemical Assay Reagents Others
    Bis(pentafluorophenyl) Oxalate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Bis(pentafluorophenyl) <em>oxalate</em>
  • HY-148669A

    Menin-MLL inhibitor 24 oxalate

    Epigenetic Reader Domain Cancer
    Menin-MLL inhibitor 24 (compound A) oxalate is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer .
    Bleximenib <em>oxalate</em>
  • HY-10261D

    BIBW 2992 oxalate

    EGFR Autophagy Apoptosis c-Met/HGFR Akt Cancer
    Afatinib (BIBW 2992) oxalate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib oxalate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
    Afatinib <em>oxalate</em>
  • HY-103110A

    5-HT Receptor Adrenergic Receptor Neurological Disease
    ST1936 oxalate is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 oxalate also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor .
    ST1936 <em>oxalate</em>
  • HY-132475S

    Isotope-Labeled Compounds Neurological Disease
    rac Duloxetine 3-Thiophene Isomer-d3 Oxalate is a stable isotope of Duloxetine.
    rac-Duloxetine-d3 <em>oxalate</em>
  • HY-103113

    5-HT Receptor Neurological Disease
    MS 245 oxalate is a potent antagonist of 5-HT6 receptor with a Ki of 2 nM .
    MS 245 <em>oxalate</em>
  • HY-W042438

    Biochemical Assay Reagents Others
    Bis(2,4,6-trichlorophenyl) oxalate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Bis(2,4,6-trichlorophenyl) <em>oxalate</em>
  • HY-100970

    4F 4PP (oxalate) is a selective 5-HT2A antagonist with almost as high affinity (Ki= 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki= 620 nM) .
    4F 4PP <em>oxalate</em>
  • HY-W099490

    Fluorescent Dye Others
    Bis[3,4,6-trichloro-2-(pentyloxycarbonyl)phenyl] oxalate is a fluorescent dye that can be used for generation of chemiluminescence .
    Bis[3,4,6-trichloro-2-(pentyloxycarbonyl)phenyl] <em>oxalate</em>
  • HY-132613

    Small Interfering RNA (siRNA) Metabolic Disease
    Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
    Lumasiran sodium
  • HY-132588

    ALN-G01

    Small Interfering RNA (siRNA) Metabolic Disease
    Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) .
    Lumasiran
  • HY-149276

    GLUT Metabolic Disease
    SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea .
    SLC26A3-IN-2
  • HY-149802

    GLUT Metabolic Disease
    SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea .
    SLC26A3-IN-1
  • HY-148610

    Others Metabolic Disease
    LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1) .
    LDH-IN-2
  • HY-W176012

    Others Metabolic Disease
    Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1) .
    Glycolate oxidase-IN-1
  • HY-113013

    β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid

    Endogenous Metabolite Metabolic Disease
    Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
    Hydroxypyruvic acid
  • HY-113013A

    β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate

    Endogenous Metabolite Metabolic Disease
    Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
    Hydroxypyruvic acid lithium hydrate

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