2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. LDN-211904 oxalate

LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC.

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LDN-211904 oxalate Chemical Structure

LDN-211904 oxalate Chemical Structure

CAS No. : 1198408-78-4

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LDN-211904 oxalate Related Antibodies

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Description

LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC[1][2].

IC50 & Target

IC50: 0.079 µM (EphB3)[1]
Molecular Weight

444.87

Formula

C21H21ClN4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(O)=O)O.O=C(C1=CN=C2C=CC(C3CCNCC3)=CN21)NC4=C(Cl)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95.0%

COA (249 KB)

Handling Instructions (2659 KB)
References
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LDN-211904 oxalate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDN-2119041198408-78-4LDN211904LDN 211904Ephrin Receptormetabolic stabilitySW48R tumor cellsCSC stemnessCRCInhibitorinhibitorinhibit

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