2. Membrane Transporter/Ion Channel
  3. GLUT
  4. SLC26A3-IN-2

SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea.

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SLC26A3-IN-2 Chemical Structure

SLC26A3-IN-2 Chemical Structure

CAS No. : 950348-60-4

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Based on 1 publication(s) in Google Scholar

SLC26A3-IN-2 Related Antibodies

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Description

SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].

In Vitro

SLC26A3-IN-2 (compound 3a) (10 μM; 10 min) produces 92% inhibition rate against SLC26A3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLC26A3-IN-2 Related Antibodies
In Vivo

SLC26A3-IN-2 (10 mg/kg; po) significantly increases stool weight and number of pellets in a Loperamide (HY-B0418A)-induced model of constipation in mice, demonstrating its efficacy in increasing stool hydration in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

368.84

Formula

C19H13ClN2O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(N=C2SC=C(N12)C3=CC=CC=C3)COC4=C(C=CC=C4)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (45.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7112 mL 13.5560 mL 27.1120 mL
5 mM 0.5422 mL 2.7112 mL 5.4224 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7112 mL 13.5560 mL 27.1120 mL 67.7801 mL
5 mM 0.5422 mL 2.7112 mL 5.4224 mL 13.5560 mL
10 mM 0.2711 mL 1.3556 mL 2.7112 mL 6.7780 mL
15 mM 0.1807 mL 0.9037 mL 1.8075 mL 4.5187 mL
20 mM 0.1356 mL 0.6778 mL 1.3556 mL 3.3890 mL
25 mM 0.1084 mL 0.5422 mL 1.0845 mL 2.7112 mL
30 mM 0.0904 mL 0.4519 mL 0.9037 mL 2.2593 mL
40 mM 0.0678 mL 0.3389 mL 0.6778 mL 1.6945 mL
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SLC26A3-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC26A3-IN-2950348-60-4GLUTGlucose transporterSLC26A3chloride-losing diarrheaInhibitorinhibitorinhibit

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