SLC26A3-IN-2
Based on 1 publication(s) in Google Scholar
SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 950348-60-4
- Formula: C19H13ClN2O2S
- Molecular Weight:368.84
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) SLC26A3-IN-2
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Biological Activity
SLC26A3-IN-2 (compound 3a) (10 μM; 10 min) produces 92% inhibition rate against SLC26A3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 950348-60-4
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Appearance Solid
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Molecular Weight 368.84
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Formula C19H13ClN2O2S
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Color White to off-white
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SMILES
O=C1C=C(N=C2SC=C(N12)C3=CC=CC=C3)COC4=C(C=CC=C4)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 16.67 mg/mL (45.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7112 mL | 13.5560 mL | 27.1120 mL | 67.7801 mL |
| 5 mM | 0.5422 mL | 2.7112 mL | 5.4224 mL | 13.5560 mL | |
| 10 mM | 0.2711 mL | 1.3556 mL | 2.7112 mL | 6.7780 mL | |
| 15 mM | 0.1807 mL | 0.9037 mL | 1.8075 mL | 4.5187 mL | |
| 20 mM | 0.1356 mL | 0.6778 mL | 1.3556 mL | 3.3890 mL | |
| 25 mM | 0.1084 mL | 0.5422 mL | 1.0845 mL | 2.7112 mL | |
| 30 mM | 0.0904 mL | 0.4519 mL | 0.9037 mL | 2.2593 mL | |
| 40 mM | 0.0678 mL | 0.3389 mL | 0.6778 mL | 1.6945 mL |
SLC26A3-IN-2 Related Classifications
HY-149276 Related Classifications
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