950348-60-4
Chemical Structure
SLC26A3-IN-2
- CAS No.: 950348-60-4
- Formula:C19H13ClN2O2S
- Molecular Weight:368.84
IUPAC Name: 7-((2-chlorophenoxy)methyl)-3-phenyl-5H-thiazolo[3,2-a]pyrimidin-5-one
InChIKey: MXPJASIJFFIVEL-UHFFFAOYSA-N
SMILES: O=C1C=C(N=C2SC=C(N12)C3=CC=CC=C3)COC4=C(C=CC=C4)Cl
Biological Activity: SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
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SLC26A3-IN-2 | 99.88% | SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea. | ||||||||||||||||||||
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Keywords
