1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. GABAA receptor agent 7

GABAA receptor agent 7 

Cat. No.: HY-146099
Handling Instructions

GABAA receptor agent 7 (compoud 5c) is a potent GABAA receptor positive modulator. GABAA receptor agent 7 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 7 has the potential for the research of epilepsy.

For research use only. We do not sell to patients.

GABAA receptor agent 7 Chemical Structure

GABAA receptor agent 7 Chemical Structure

CAS No. : 2376841-18-6

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Description

GABAA receptor agent 7 (compoud 5c) is a potent GABAA receptor positive modulator. GABAA receptor agent 7 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 7 has the potential for the research of epilepsy[1].

In Vitro

GABAA receptor agent 7 (compoud 5c) shows anticonvulsant activity with an IC50 of 0.452 µM in 4-AP induced hyper-excitability Model[1].
GABAA receptor agent 7 (0.01-100 µM; 0-140 s) increases GABA-induced activation of GABAA1 receptor in a dose-dependent manner with EC50 3.08 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GABAA receptor agent 7 shows anticonvulsant activity in mice with an ED50 of 31.81 mg/kg and an TD50 of 547.89 mg/kg[1].
GABAA receptor agent 7 specifically attenuates PTZ-induced seizures but not MES-induced seizures in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

336.78

Formula

C18H13ClN4O

CAS No.
SMILES

O=C1C=C(CC2=CC=C(Cl)C=C2)N=C3N1NC(C4=CC=CC=C4)=N3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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GABAA receptor agent 7
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HY-146099
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