2. Metabolic Enzyme/Protease
  3. FABP
  4. FABP4/5-IN-7

FABP4/5-IN-7 is a dual FABP4/FABP5 inhibitor, with an IC50 of 0.8 μM and a Kd of 0.01 μM for FABP4, and an IC50 of 1.4 μM for FABP5. FABP4/5-IN-7 inhibits lipolysis in adipocytes. FABP4/5-IN-7 inhibits MCP-1 release in macrophages. FABP4/5-IN-7 improves dyslipidemia in diet-induced obese mice. FABP4/5-IN-7 can be used in studies related to dyslipidemia.

For research use only. We do not sell to patients.

FABP4/5-IN-7

FABP4/5-IN-7 Chemical Structure

CAS No. : 1227413-92-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

FABP4/5-IN-7 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FABP4/5-IN-7 is a dual FABP4/FABP5 inhibitor, with an IC50 of 0.8 μM and a Kd of 0.01 μM for FABP4, and an IC50 of 1.4 μM for FABP5. FABP4/5-IN-7 inhibits lipolysis in adipocytes. FABP4/5-IN-7 inhibits MCP-1 release in macrophages. FABP4/5-IN-7 improves dyslipidemia in diet-induced obese mice. FABP4/5-IN-7 can be used in studies related to dyslipidemia[1].

IC50 & Target

FABP4

0.8 μM (IC50)

FABP4

0.01 μM (Kd)

FABP5

1.4 μM (IC50)

FABP3

0.52 μM (Kd)

In Vitro

FABP4/5-IN-7 (Compound 2) (15-100 μM) binds to recombinant FABP4 with high affinity (Kd = 0.01 μM) and to recombinant FABP3 with lower affinity (Kd = 0.52 μM) in TdF assays[1].
FABP4/5-IN-7 (10 μM) significantly inhibits basal lipolysis in fully differentiated 3T3-L1 adipocytes[1].
FABP4/5-IN-7 (3-30 μM; 1 h pre-incubation, followed by 4 h incubation with isoproterenol) inhibits isoprenaline (HY-B0468)-stimulated lipolysis in fully differentiated 3T3-L1 adipocytes[1].
FABP4/5-IN-7 (0.008-25 μM; 4 h) inhibits isoprenaline-stimulated lipolysis in primary human adipocytes, with an IC50 of 22 μM[1].
FABP4/5-IN-7 (24 h) inhibits basal MCP-1 release from THP-1 macrophage-like cells differentiated with PMA (HY-18739), with an IC50 of 7.5 μM[1].
FABP4/5-IN-7 (0.39-25 μM; 1 h pre-incubation, followed by 3 h incubation with LPS) significantly inhibits LPS (HY-D1056)-induced MCP-1 release from PMA-differentiated THP-1 macrophage-like cells at the concentration of 25 μM[1].
FABP4/5-IN-7 (1-25 μM; overnight) inhibits MCP-1 release from primary human macrophages at a concentration of 25 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FABP4/5-IN-7 Related Antibodies
In Vivo

FABP4/5-IN-7 (30 mg/kg; p.o.; once daily; for 8 weeks) slightly improves insulin sensitivity in leptin-deficient obese mice without altering their body weight[1].
FABP4/5-IN-7 (30 mg/kg; p.o.; daily; for 3 consecutive days) shows a fat/plasma concentration ratio of 0.09 in diet-induced obese mice, with the proportion of free drug in plasma being <1%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (leptin-deficient Lep^ob/Lep^ob)[1]
Dosage: 30 mg/kg
Administration: diet; daily; 8 weeks
Result: Produced a minor improvement in intraperitoneal insulin tolerance tests.
Showed no decrease in body weight.
Animal Model: C57BL/6J mice (diet-induced obesity, DIO)[1]
Dosage: 30 mg/kg
Administration: diet; daily; 3 days
Result: Achieved a fat/plasma concentration ratio of 0.09.
Resulted in <1% free drug fraction in plasma.
Molecular Weight

366.80

Formula

C19H15ClN4O2
CAS No.
SMILES

O=C1C=C(COC2=C(C)C(Cl)=CC=C2)N=C3NC(C4=CC=CC=C4)=NN13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

FABP4/5-IN-7 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FABP4/5-IN-71227413-92-4FABPFatty acid-binding proteinleptin-deficient obese miceadipocytesmacrophages3T3-L1 adipocytesprimary human macrophagesFABP5THP-1 macrophage-like cellsprimary human adipocytesFABP4diet-induced obese miceInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FABP4/5-IN-7
Cat. No.:
HY-183836
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.