2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. (-)-p-Bromotetramisole oxalate

(-)-p-Bromotetramisole oxalate  (Synonyms: L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate)

Cat. No.: HY-19695 Purity: 99.78%
COA
SDS
Handling Instructions Technical Support

(-)-p-Bromotetramisole oxalate (L-p-Bromotetramisole oxalate) is an alkaline phosphatase inhibitor. (-)-p-Bromotetramisole (oxalate) is applicable to research related to erythroleukemia.

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(-)-p-Bromotetramisole oxalate

(-)-p-Bromotetramisole oxalate 화학구조

CAS No. : 62284-79-1

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

(-)-p-Bromotetramisole oxalate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (-)-p-Bromotetramisole oxalate

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

(-)-p-Bromotetramisole oxalate (L-p-Bromotetramisole oxalate) is an alkaline phosphatase inhibitor. (-)-p-Bromotetramisole (oxalate) is applicable to research related to erythroleukemia[1][2].

In Vitro

(-)-p-Bromotetramisole oxalate (0.3-0.4 mM; 5 days) potently inhibits terminal cell division-associated MEL DS-19 cell differentiation induced by 0.7% DMSO (HY-Y0320) or 1.2 mM HMBA (HY-124284), reducing B+ cell levels[1].
(-)-p-Bromotetramisole oxalate (10-100 μM) potently inhibits purified human liver, bone, spleen, and kidney alkaline phosphatase isoenzymes while minimally inhibiting purified human intestinal and placental alkaline phosphatase isoenzymes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-p-Bromotetramisole oxalate Related Antibodies

Cell Differentiation Assay[1]

Cell Line: mouse erythroleukemia (MEL) DS-19 cells
Concentration: 0.3 mM; 0.4 mM
Incubation Time: 5 days
Result: Reduced the percentage of Benzidine-staining, Hemoglobin (HY-P2995)-containing (B+) cells of the inducer-only control at 0.3 mM (0.7% DMSO-induced differentiation).
Reduced 0.7% DMSO-induced B+ cells of the control at 0.4 mM.
Reduced 1.2 mM HMBA-induced B+ cells of the inducer-only control at 0.4 mM.
분자량

373.22

화학식

C13H13BrN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

BrC1=CC=C([C@@H]2N=C3SCCN3C2)C=C1.O=C(O)C(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

DMSO : ≥ 29 mg/mL (77.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 25 mg/mL (66.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6794 mL 13.3969 mL 26.7938 mL
5 mM 0.5359 mL 2.6794 mL 5.3588 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.70 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.88%

SDS (393 KB)

COA (252 KB) HNMR (216 KB) LCMS (121 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.6794 mL 13.3969 mL 26.7938 mL 66.9846 mL
5 mM 0.5359 mL 2.6794 mL 5.3588 mL 13.3969 mL
10 mM 0.2679 mL 1.3397 mL 2.6794 mL 6.6985 mL
15 mM 0.1786 mL 0.8931 mL 1.7863 mL 4.4656 mL
20 mM 0.1340 mL 0.6698 mL 1.3397 mL 3.3492 mL
25 mM 0.1072 mL 0.5359 mL 1.0718 mL 2.6794 mL
30 mM 0.0893 mL 0.4466 mL 0.8931 mL 2.2328 mL
40 mM 0.0670 mL 0.3349 mL 0.6698 mL 1.6746 mL
50 mM 0.0536 mL 0.2679 mL 0.5359 mL 1.3397 mL
60 mM 0.0447 mL 0.2233 mL 0.4466 mL 1.1164 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(-)-p-Bromotetramisole oxalate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-p-Bromotetramisole62284-79-1L-p-Bromotetramisole6-BromolevamisolePhosphatasehuman placental alkaline phosphataseerythroleukemia cellshuman liver alkaline phosphatasealkaline phosphataseintestinal alkaline phosphatasehuman bone alkaline phosphatasehuman spleen alkaline phosphataseMEL DS-19 cellmammalian alkaline phosphataseshuman kidney alkaline phosphataseInhibitorinhibitorinhibit

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상품명:
(-)-p-Bromotetramisole oxalate
Cat. No.:
HY-19695
수량:
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