1. Metabolic Enzyme/Protease
  2. Phosphatase

F1063-0967 

Cat. No.: HY-101510 Purity: 98.28%
Handling Instructions

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.

For research use only. We do not sell to patients.

F1063-0967 Chemical Structure

F1063-0967 Chemical Structure

CAS No. : 613225-56-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 352 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.

IC50 & Target

IC50: 11.62 μM (DUSP26)[1]

In Vitro

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM. At concentration above 0.1 μM, F1063-0967 remarkably induces IMR32 cell apoptosis. F1063-0967 induces apoptosis in IMR-32 cell line with an IC50 value of 4.13 μM. F1063-0967 has no effect on HL7702 cell line, and little inhibition effect on SH-SY5Y cell line[1].

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (257.95 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0636 mL 10.3180 mL 20.6360 mL
5 mM 0.4127 mL 2.0636 mL 4.1272 mL
10 mM 0.2064 mL 1.0318 mL 2.0636 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

The IMR-32 cells are plated in 96-well plates with 1×103 cells per well. After the cells are allowed to settle for 24 h, F1063-0967 (0, 10, 1, and 0.1 μM) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 μM) is added, then MTT assays are carried out after 72 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

484.59

Formula

C₂₄H₂₄N₂O₅S₂

CAS No.

613225-56-2

SMILES

OC1=C(C(O)=O)C=CC(NC(CCCCCN2C(S/C(C2=O)=C\C3=CC=C(C)C=C3)=S)=O)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
F1063-0967
Cat. No.:
HY-101510
Quantity:

F1063-0967

Cat. No.: HY-101510