1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Calyculin A

Calyculin A  (Synonyms: (-)-Calyculin A)

Cat. No.: HY-18983 Purity: ≥99.0%
COA Handling Instructions

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.

For research use only. We do not sell to patients.

Calyculin A Chemical Structure

Calyculin A Chemical Structure

CAS No. : 101932-71-2

Size Price Stock Quantity
10 μg (0.5 mM * 20 μL in DMSO) USD 120 In-stock
25 μg (0.5 mM * 50 μL in DMSO) USD 250 In-stock
50 μg (0.5 mM * 100 μL in DMSO) USD 380 In-stock
100 μg (0.5 mM * 200 μL in DMSO) USD 580 In-stock
Synthetic products have potential research and development risk.

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 13 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review


Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively[1].

IC50 & Target

IC50: 2 nM (PP1); 0.5-1 nM (PP2A)[1]

In Vitro

Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Human osteosarcoma MG63 cells
Concentration: 0, 1, 2, 5, 10 nM
Incubation Time: 24 hours
Result: Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures.
Molecular Weight







Colorless to light yellow




Room temperature in continental US; may vary elsewhere.


Solution, -20°C, 2 years

Purity & Documentation

Purity: 99.67%

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Calyculin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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