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Calyculin A

(Synonyms: (-)-Calyculin A)
20 Cited Publications
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Based on 20 publication(s) in Google Scholar

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.

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  • Pureté : 98%
  • CAS No.: 101932-71-2
  • Formule: C50H81N4O15P
  • Masse moléculaire:1009.17
  • Stockage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Calyculin A Chemical Structure
    Calyculin A Chemical Structure
  • Experimental Validation Results for Calyculin A
  • Experimental Validation Results for Calyculin A
  • Experimental Validation Results for Calyculin A
CAS No.: 101932-71-2
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609-228-6898
[email protected] [email protected]
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  • Calyculin A Chemical Structure
    Calyculin A Chemical Structure
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    MedChemExpress Validation
    HeLa cells were cultured in 6 cm dishes to approximately 70% confluence and then treated with Calyculin A (HY-18983) at concentration of 10 nM for 30 mins. Phospho-FAK (Tyr397) protein expression was subsequently analyzed by Western blot. The results demonstrated that Calyculin A induced phosphorylation of FAK (Tyr397). Primary antibodies used: Phospho-FAK (Tyr397) Antibody (HY-P87691) and GAPDH Antibody (HY-P80954A).

  • 1/16

    MedChemExpress Validation
    HeLa cells were cultured in 6 cm dishes to approximately 70% confluence and then treated with Calyculin A (HY-18983) at concentration of 10 and 25 nM for 30 mins. Phospho-GSK3 beta (Ser9) protein expression was subsequently analyzed by Western blot. The results demonstrated that Calyculin A induced phosphorylation of GSK3 beta (Ser9). Primary antibodies used: Phospho-GSK3 beta (Ser9) Antibody (HY-P86595) and GAPDH Antibody (HY-P80954A).

  • 1/16

    MedChemExpress Validation
    Jurkat cells were cultured in 6 cm dishes to approximately 70% confluence and then treated with Calyculin A (HY-18983) at concentration of 100 nM for 30 mins. Phospho-Rb (Thr356) protein expression was subsequently analyzed by Western blot. The results demonstrated that Calyculin A induced phosphorylation of Rb (Thr356). Primary antibodies used: Phospho-Rb (Thr356) Antibody (HY-P81301) and GAPDH Antibody (HY-P80954A).

  • Calyculin A