1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. ST1936 oxalate

ST1936 oxalate 

Cat. No.: HY-103110A
Handling Instructions

ST1936 oxalate is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 oxalate also shows moderate affinity (Ki of 300 nM) for human α2 adrenergic receptor.

For research use only. We do not sell to patients.

ST1936 oxalate Chemical Structure

ST1936 oxalate Chemical Structure

CAS No. : 1782228-83-4

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Description

ST1936 oxalate is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 oxalate also shows moderate affinity (Ki of 300 nM) for human α2 adrenergic receptor[1].

IC50 & Target[1]

5-HT6 Receptor

13 nM (Ki)

Human 5-HT7 Receptor

168 nM (Ki)

5-HT2B Receptor

245 nM (Ki)

In Vitro

ST1936 appears to be relatively selective for 5-HT6 receptors, although it has shown affinity also for 5-HT2B, 5-HT1A, 5-HT7 receptor and α-adrenergic receptors when tested in a broad crossreactivity panel that comprised G-protein-coupled receptors, ion channel binding sites, enzymes, and transporters[1].

In Vivo

In-vivo electrophysiological studies are performed to investigate the physiological role of 5-HT6 receptors in the control of the function of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA). Extracellular single-unit recordings are performed from putative dopamine-containing neurons in the SNc and VTA of anesthetised rats (Male Sprague-Dawley rats). In the SNc, acute systemic administration of ST1936 (Intravenous injection; 50–1600 µg/kg for the SNc; 50–400 µg/kg for the VTA) has no effects on basal firing activity of these dopamine neurons; however, in the VTA, ST1936 induces either dose-related increases (45% of cells) or decreases in basal activity of these dopaminergic neurons[1].

Molecular Weight

326.78

Formula

C₁₅H₁₉ClN₂O₄

CAS No.

1782228-83-4

SMILES

CC(N1)=C(CCN(C)C)C2=C1C=CC(Cl)=C2.O=C(O)C(O)=O

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ST1936ST 1936ST-19365-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT6electrophysiologicaldopamineneuronsVTA5-HT75-HT2Bα2-adrenergicInhibitorinhibitorinhibit

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ST1936 oxalate
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HY-103110A
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