(R)-Citalopram oxalate
Based on 1 Customer Validation
(R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a serotonin reuptake inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression.
For research use only. We do not sell to patients.
- Purity: 99.52%
- CAS No.: 219861-53-7
- Formula: C22H23FN2O5
- Molecular Weight:414.43
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
(R)-Citalopram (Ki = 330 nM) oxalate is approximately 60 times more weak than S-citalopram (Ki = 5 nM) in Iinhibition of the 5-HT-induced current in hSERT-expressing Xenopus oocytes[2].
R-citalopram oxalate attenuates the S-citalopram-induced inhibition of SERT[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NMRI/BOM (male, 18-25 g)[2]
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Dosage:1 mg/kg; 2 mg/kg; 3.9 mg/kg; 7.8 mg/kg
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Administration:s.c.; single dose
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Result:When coapplied with S-citalopram in ratios of 2 : 1 and 4 : 1, there was – except for 2 mg S-citalopram + 3.9 mg R-citalopram – a statistically significant reduction in the effect of S-citalopram.
Appeared to be antagonist specific for S-citalopram.
Chemical Information
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CAS No. 219861-53-7
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Appearance Solid
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Molecular Weight 414.43
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Formula C22H23FN2O5
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Color White to off-white
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SMILES
OC(C(O)=O)=O.CN(C)CCC[C@@]1(C2=CC=C(C=C2)F)C3=CC=C(C#N)C=C3CO1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Bezchlibnyk-Butler K, et al. Citalopram--a review of pharmacological and clinical effects. J Psychiatry Neurosci. 2000 May;25(3):241-54. [Content Brief]
[2]. Stórustovu Sí, et al. R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter. Br J Pharmacol. 2004 May;142(1):172-80. [Content Brief]
[3]. Sánchez C. The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram. Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):91-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-Citalopram oxalate Related Classifications
HY-110289 Related Classifications
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