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Cat. No.: HY-19668A

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SGS518 oxalate

SGS518 oxalate is a selective 5-HT₆R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses^[1]

For research use only. We do not sell to patients.

CAS No.: 445441-27-0
Formula: C₂₃H₂₄F₂N₂O₇S
Molecular Weight:510.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

SGS518 oxalate Chemical Structure

CAS No.: 445441-27-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target [1]

5-HT₆ Receptor

All 5-HT Receptor Isoforms :

In Vivo

SGS518 oxalate (30 mg/kg; i.p. for 30 min) protects Abca4^–/–Rdh8 sup>–/– mouse retinas from light-induced damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Abca4^–/–Rdh8 sup>–/–mice are exposed at white light^[1]
Dosage:

30 mg/kg
Administration:

I.p. injection for 30 minutes
Result:

A marked preservation of the photoreceptor layer.
Reduced formation of autofluorescent spots in mice.
Protected retinal morphology.

Chemical Information

CAS No. 445441-27-0
Molecular Weight 510.51
Formula C₂₃H₂₄F₂N₂O₇S
SMILES

O=S(C1=C(F)C=CC=C1F)(OC2=CC3=C(N(C)C=C3C4CCN(C)CC4)C=C2)=O.O=C(O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Y, et, al. Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest. 2013 Dec; 123(12): 5119-34. [Content Brief]

Calculators

Molarity Calculator

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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