1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SGS518 oxalate

SGS518 oxalate 

Cat. No.: HY-19668A
Handling Instructions

SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses[1]

For research use only. We do not sell to patients.

SGS518 oxalate Chemical Structure

SGS518 oxalate Chemical Structure

CAS No. : 445441-27-0

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Description

SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses[1]

IC50 & Target[1]

5-HT6 Receptor

 

In Vivo

SGS518 oxalate (30 mg/kg; i.p. for 30 min) protects Abca4–/–Rdh8 sup>–/– mouse retinas from light-induced damage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Abca4–/–Rdh8 sup>–/–mice are exposed at white light[1]
Dosage: 30 mg/kg
Administration: I.p. injection for 30 minutes
Result: A marked preservation of the photoreceptor layer.
Reduced formation of autofluorescent spots in mice.
Protected retinal morphology.
Molecular Weight

510.51

Formula

C₂₃H₂₄F₂N₂O₇S

CAS No.

445441-27-0

SMILES

O=S(C1=C(F)C=CC=C1F)(OC2=CC3=C(N(C)C=C3C4CCN(C)CC4)C=C2)=O.O=C(O)C(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SGS518SGS 518SGS-5185-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT6RcognitiveimpairmentsamnesiaanxietydepressionretinaInhibitorinhibitorinhibit

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SGS518 oxalate
Cat. No.:
HY-19668A
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