Sucrose
Based on 10 publication(s) in Google Scholar
Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 57-50-1
- Formula: C12H22O11
- Molecular Weight:342.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sucrose
More- Signal Transduct Target Ther. 2025 Nov 18;10(1):373. [Abstract]
- Nat Nanotechnol. 2025 Feb;20(2):296-302. [Abstract]
- Autophagy. 2023 Jun;19(6):1745-1763. [Abstract]
- Food Chem. 2025 May 31:489:144992. [Abstract]
- Food Chem. 2023 Mar 30;405(Pt A):134807. [Abstract]
- Front Immunol. 2021 Aug 2;12:686846. [Abstract]
- Vaccines. 2026 Jan 21;14(1):106. [Abstract]
- Mol Biotechnol. 2023 Dec;65(12):2061-2070. [Abstract]
- J Vis Exp. 2025 Jun 17:(220). [Abstract]
- SSRN. 2026 Mar 3.
Customer Validation & Images
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
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WB
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>30 μM
Compound: 8
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Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
| BV-2 | IC50 |
>200 μM
Compound: 8
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Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay
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[PMID: 25466198] |
| HCT-15 | IC50 |
>30 μM
Compound: 8
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Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
| SK-MEL-2 | IC50 |
>30 μM
Compound: 8
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Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
| SK-OV-3 | IC50 |
>30 μM
Compound: 8
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Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by SRB assay
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[PMID: 25466198] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 57-50-1
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Appearance Solid
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Molecular Weight 342.30
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Formula C12H22O11
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@]2(CO)[C@@H](O)[C@H](O)[C@@H](CO)O2
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Synonyms
D-(+)-Saccharose
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (10)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer. [Abstract]2025 Nov 18;10(1):373. PMID: 41249116 -
Nat Nanotechnol
2025 Feb;20(2):296-302. PMID: 39468359
Sucrose purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Feb;20(2):296-302. [Abstract]
EGFR degradation in MDA-MB-231 cells after incubation with 500 nM NTZ-NPs and 75 mM Sucrose for 24 h.
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Autophagy
The Valsa mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple. [Abstract]2023 Jun;19(6):1745-1763. PMID: 36449354 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 May 31:489:144992. PMID: 40466530 -
Food Chem
Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]2023 Mar 30;405(Pt A):134807. PMID: 36370576 -
Front Immunol
Mannose Receptor Mediates the Activation of Chitooligosaccharides on Blunt Snout Bream ( Megalobrama amblycephala) Macrophages. [Abstract]2021 Aug 2;12:686846. PMID: 34408745 -
Vaccines
Preparation and Efficacy Evaluation of Heat-Resistant Freeze-Dried Live-Attenuated Vaccine Formulation of Micropterus salmoides Rhabdovirus. [Abstract]2026 Jan 21;14(1):106. PMID: 41601021
Sucrose purchased from MedChemExpress. Usage Cited in: Vaccines. 2026 Jan 21;14(1):106. [Abstract]
Pretreat cells with endocytosis inhibitors (Sucrose; 300 mM; 2 h) or absence (control) and observe the uptake of fluorescein isothiocyanate (FITC)-COS6 by macrophages under a confocal microscope. The co-localization percentage of FITC-COS6 and nucleus was analyzed using WCIF ImageJ software.
Sucrose purchased from MedChemExpress. Usage Cited in: Vaccines. 2026 Jan 21;14(1):106. [Abstract]
Cells were treated with endocytosis inhibitors (Sucrose; 300 mM) and incubated with FITC-labeled COS6, washed, lysed, and mixed uniformly. Fluorescence intensity was measured.
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Mol Biotechnol
Inhibition of γδ T Cells Alleviates Blood-Brain Barrier in Cardiac Arrest and Cardiopulmonary Resuscitation in Mice. [Abstract]2023 Dec;65(12):2061-2070. PMID: 36944895 -
J Vis Exp
Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation. [Abstract]2025 Jun 17:(220). PMID: 40622958 -
Solvent & Solubility
H2O : 100 mg/mL (292.14 mM; Need ultrasonic and warming)
DMSO : 100 mg/mL (292.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (292.14 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
A total of 66 male 8-wk-old Sprague-Dawley obesity-prone (OP) and obesity-resistant (OR) rats (n = 38 per each phenotype), weighing 275 g and 210 g respectively, are used in this study. After recovery and attaining pre-surgical weights, rats undergo three training trials of 60-min sham feeding sessions with 0.03 M Sucrose solution. During testing, rats are briefly deprived of water (0900 to 1600 h) but not food, and are tested for 1 h (1400 to1500 h) sham intake of 0.03 M Sucrose solution until a stable baseline is achieved. Afterwards, rats are sham fed one of three Sucrose solutions (0.03, 0.3, and 1.0 M) in random order, every other day, with each concentration tested at least twice. Sucrose intake is individually recorded every 5 min for 60 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 2.9214 mL | 14.6071 mL | 29.2141 mL | 73.0354 mL |
| 5 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 14.6071 mL | |
| 10 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 7.3035 mL | |
| 15 mM | 0.1948 mL | 0.9738 mL | 1.9476 mL | 4.8690 mL | |
| 20 mM | 0.1461 mL | 0.7304 mL | 1.4607 mL | 3.6518 mL | |
| 25 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9214 mL | |
| 30 mM | 0.0974 mL | 0.4869 mL | 0.9738 mL | 2.4345 mL | |
| 40 mM | 0.0730 mL | 0.3652 mL | 0.7304 mL | 1.8259 mL | |
| 50 mM | 0.0584 mL | 0.2921 mL | 0.5843 mL | 1.4607 mL | |
| 60 mM | 0.0487 mL | 0.2435 mL | 0.4869 mL | 1.2173 mL | |
| 80 mM | 0.0365 mL | 0.1826 mL | 0.3652 mL | 0.9129 mL | |
| 100 mM | 0.0292 mL | 0.1461 mL | 0.2921 mL | 0.7304 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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