Phosphofructokinase,Bacillus stearothermophilus
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Phosphofructokinase,Bacillus stearothermophilus is a glycolytic enzyme and also an allosteric activation target of fructose-2,6-bisphosphate. PFK1 supports cardiac glycolysis to maintain normal cardiac function and mediates adaptive responses to pressure overload. Upregulated expression and activity of PFK1 are associated with the alleviation of pathological changes induced by pressure overload, including diastolic dysfunction, interstitial fibrosis and myocardial hypertrophy. Inhibition of PFK1 redirects glucose carbon flux to the pentose phosphate pathway. PFK1 promotes proliferation, migration and glycolysis of colorectal cancer cells, reduces apoptosis and decreases their radiosensitivity, and shows higher expression levels in radioresistant tumors. PFK1 can be used in research related to diastolic dysfunction heart failure and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 9001-80-3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Phosphofructokinase,Bacillus stearothermophilus enables the quantitative detection of fructose-2,6-bisphosphate levels via a coupled-enzyme cell-free assay[1].
Phosphofructokinase,Bacillus stearothermophilus (PFK1) is expressed in a variety of human colorectal cancer (CRC) cell lines, with the highest expression level detected in HT29 cells; in addition, its expression level in radioresistant tumors is significantly higher than that in radiosensitive tumors[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9001-80-3
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Appearance Solid
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Color White to off-white
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SMILES
[Phosphofructokinase,Bacillus stearothermophilus]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. He X, et al. Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure. Journal of cellular physiology. 2022 Aug;237(8):3317-3327. [Content Brief]
[2]. Miyazawa H, et al. Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching. Development (Cambridge, England). 2017 Jan 01;144(1):63-73. [Content Brief]
[3]. Tian RF, et al. SiRNA targeting PFK1 inhibits proliferation and migration and enhances radiosensitivity by suppressing glycolysis in colorectal cancer. American journal of translational research. 2020;12(9):4923-4940. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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