1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. PNU-282987

PNU-282987 

Cat. No.: HY-12560A Purity: 99.70%
Handling Instructions

PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).

For research use only. We do not sell to patients.

PNU-282987 Chemical Structure

PNU-282987 Chemical Structure

CAS No. : 123464-89-1

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
10 mg USD 79 In-stock
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
Estimated Time of Arrival: December 31
100 mg USD 528 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). IC50 value: 26 nM(Ki) [1] Target: α7 nAChR agonist in vitro: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion [3]. in vivo: Mice were subjected to 70% partial hepatic I/R for 60 min and pretreated with either vehicle or with PNU-282987, and blood and hepatic tissue samples were collected at 3, 6, and 12 h following reperfusion. pretreatment with PNU-282987 decreased serum transaminase levels and ameliorated liver injury after hepatic I/R. Moreover, pretreatment with PNU-282987 suppressed NF-κB activation, cytokine production (tumor necrosis factor α, interleukin 1β), and HMGB1 expression in liver after hepatic I/R [2]. Mice treated with 2.5 and 10 mg/kg of PNU devoted less time to rearing into open arms. In the HB task, MC mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE and SE, whereas EE displayed low exploration levels reflected in total HD (5 min) [4].

Molecular Weight

301.21

Formula

C₁₄H₁₈Cl₂N₂O

CAS No.

123464-89-1

SMILES

O=C(N[[email protected]]1CN2CCC1CC2)C3=CC=C(Cl)C=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 61 mg/mL (202.52 mM)

H2O : 50 mg/mL (166.00 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3199 mL 16.5997 mL 33.1994 mL
5 mM 0.6640 mL 3.3199 mL 6.6399 mL
10 mM 0.3320 mL 1.6600 mL 3.3199 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    PNU-282987 is dissolved in saline[5].

References

Purity: 99.70%

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Keywords:

PNU-282987PNU282987PNU 282987nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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PNU-282987
Cat. No.:
HY-12560A
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