(S)-PNU-282987 hydrochloride 

(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC₅₀ of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT₃ receptor with an IC₅₀ of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems^[1].

PNU-282987 (free base) (Compound C7) can replace the R7 selective antagonist methylaconitine (MLA) in rat brain homogenate with a K_i of 27 nM^[1].
PNU-282987 has α7 nAChR agonist activity with an EC₅₀ of 154 nM^[1].
PNU-282987 also inhibits the 5-HT₃ receptor with an IC₅₀ value of 4541 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit^[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

301.21

C₁₄H₁₈Cl₂N₂O

128311-08-0

O=C(C1=CC=C(Cl)C=C1)N[C@H]2C3CCN(CC3)C2.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.  [Content Brief]