1. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis Anti-infection
  2. Potassium Channel nAChR Apoptosis Bacterial Parasite
  3. Dequalinium Chloride

Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity.

For research use only. We do not sell to patients.

Dequalinium Chloride Chemical Structure

Dequalinium Chloride Chemical Structure

CAS No. : 522-51-0

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Based on 1 publication(s) in Google Scholar

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Description

Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity[1][2][3][4].

In Vitro

Dequalinium chloride blocks angiotensin II (100 nM)-evoked K+ loss in guinea-pig hepatocytes, with an IC50 of 1.5 μM[5].
Dequalinium (0-100 μg/mL, 72 h) chloride inhibits cell growth in human Pca cell lines (PC3, DU145, LNCaP, MDA-PCA-2B), and induces cell apoptosis in PC3 cells (0.9 μM, 4 h)[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dequalinium chloride shows a LD50 of 18.3 mg/kg in mice (i.p., a single time)[2].
Dequalinium chloride (2 mg/kg, i.p., daily for 10 days) inhibits the tumor growth of mouse bladder carcinoma MB49[3].
Dequalinium chloride (2 mg/kg, s.c.) reduces Diisopropylfluorophosphate-induced tremors (organophosphate poisoning) in mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

527.57

Formula

C30H40Cl2N4

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=[N+](C2=CC=CC=C2C(N)=C1)CCCCCCCCCC[N+](C3=CC=CC=C3C(N)=C4)=C4C.[Cl-].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (insoluble)

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Purity & Documentation

Purity: 99.91%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Dequalinium Chloride
Cat. No.:
HY-B0567
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