522-51-0
522-51-0
Chemical Structure
Dequalinium Chloride
- CAS No.: 522-51-0
- Formula:C30H40Cl2N4
- Molecular Weight:527.57
IUPAC Name: 1,1'-(decane-1,10-diyl)bis(4-amino-2-methylquinolin-1-ium) chloride
InChIKey: LTNZEXKYNRNOGT-UHFFFAOYSA-N
SMILES: CC1=[N+](C2=CC=CC=C2C(N)=C1)CCCCCCCCCC[N+](C3=CC=CC=C3C(N)=C4)=C4C.[Cl-].[Cl-]
Biological Activity: Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity[1][2][3][4].
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Dequalinium Chloride | 99.72% | Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity. | ||||||||||||||||||||
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Dequalinium Chloride (Standard) | ≥98% | Dequalinium (Chloride) (Standard) is the analytical standard of Dequalinium (Chloride). This product is intended for research and analytical applications. Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity. | ||||||||||||||||||||
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References
- [1]. Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95(16): p. 1108-10. [Content Brief]
- [2]. Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. J Pharm Sci, 1993. 82(3): p. 231-5. [Content Brief]
- [3]. Belanger-Coast MG, et al. Dequalinium chloride is an antagonists of α7 nicotinic acetylcholine receptors. Eur J Pharmacol. 2022 Jun 15;925:175000. [Content Brief]
- [4]. Mendling W, et al. Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review. Arch Gynecol Obstet. 2016 Mar;293(3):469-84. [Content Brief]
