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Rocuronium Bromide (Synonyms: ORG 9426 (Bromide))

Cat. No.: HY-17440 Purity: >98.0%
Handling Instructions

Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.

For research use only. We do not sell to patients.

Rocuronium Bromide Chemical Structure

Rocuronium Bromide Chemical Structure

CAS No. : 119302-91-9

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10 mM * 1 mL in DMSO USD 66 In-stock
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10 mg USD 60 In-stock
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100 mg USD 114 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Rocuronium Bromide:

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Description

Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.

In Vitro

Rocuronium reduced the indirectly elicited twitch tensions in normal (50% inhibitory concentration [IC(50)], 9.84 [9.64-10.04] μM, mean [95% confidence interval]) and all pretreated diaphragms (P < .01, n = 6) in a concentration-dependent fashion [1]. The ED95 of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for adults. Rocuronium is readily reversed with conventional doses of cholinesterase-inhibiting drugs [2]. Onset time until maximum block, duration until 25% recovery of twitch height, and recovery from 25 until 75% of twitch height were 1.7 (32), 53 (19) and 20 (37) min, respectively [3].

In Vivo

Only 8.7±5.7% (SD) and 6.0±2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4±9.2% and 52.4±9.2% of an injected dose of ORG 9426 and 35.7±12.2% and 46.8±9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively [4].

Clinical Trial
Molecular Weight

609.68

Formula

C₃₂H₅₃BrN₂O₄

CAS No.

119302-91-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 155 mg/mL (254.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6402 mL 8.2010 mL 16.4020 mL
5 mM 0.3280 mL 1.6402 mL 3.2804 mL
10 mM 0.1640 mL 0.8201 mL 1.6402 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Rocuronium Bromide
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HY-17440
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