1. Metabolic Enzyme/Protease
  2. RAR/RXR
    Endogenous Metabolite
  3. Isotretinoin

Isotretinoin (Synonyms: 13-cis-Retinoic acid)

Cat. No.: HY-15127 Purity: 99.88%
Handling Instructions

Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne.

For research use only. We do not sell to patients.

Isotretinoin Chemical Structure

Isotretinoin Chemical Structure

CAS No. : 4759-48-2

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Free Sample (0.5-1 mg)   Apply Now  
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 126 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Isotretinoin:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review


Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. Target: RAR/RXR Isotretinoin has been the most effective and long-lasting drug for the treatment of severe acne for more than 30 years and can achieve long-term remission in 70-80% of patients after a single course. The new evidence-based European S3-guideline recommends the use of Isotretinoin as a first-line medication for the treatment of severe papulopustular or conglobate acne, especially when prognostically unfavorable factors are present: family history of acne, early onset, marked seborrhea, localization on the trunk, scarring, psychosocial disability or persistent/late-type acne [1]. Five patients with pityriasis rubra pilaris were treated with isotretinoin from September 1982 through 1985. Isotretinoin at an average dose of 1.16 mg/kg/day for 16 to 24 weeks caused complete or almost complete clearing in four of the five patients [2]. isotretinoin produces significant anti-inflammatory effects by inhibition of monocyte and neutrophil chemotaxis across intact biologic barriers in vivo [3]. Isotretinoin 5 mg/day is effective in reducing the number of acne lesions, and improving patients dermatologic quality of life, with minimal adverse effects [4]. Clinical indications: Acne Toxicity: Isotretinoin is teratogenic. It also causes mucocutaneous side effects suck as cheilitis, dry skin, and dry eyes.

IC50 & Target

Human Endogenous Metabolite


Clinical Trial
Molecular Weight







Room temperature in continental US; may vary elsewhere.


-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (166.42 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3285 mL 16.6423 mL 33.2845 mL
5 mM 0.6657 mL 3.3285 mL 6.6569 mL
10 mM 0.3328 mL 1.6642 mL 3.3285 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (8.32 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.92 mM); Clear solution

*All of the co-solvents are available by MCE.
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