Isotretinoin-d₅

Cat. No.: HY-15127S: Fiche technique Instruction de manipulation
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Isotretinoin-d₅ is the deuterium labeled Isotretinoin. Isotretinoin is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity.

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Isotretinoin-d₅ Chemical Structure

Size	Stock	Quantité
500 μg	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
1 mg	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Obtenir un devis
10 mg	Obtenir un devis

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Other Forms of Isotretinoin-d₅:

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Activité biologique
Pureté et documentation
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Description	Isotretinoin-d₅ is the deuterium labeled Isotretinoin. Isotretinoin is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity^[1]^[2]^[3].
Application	1. This compound can be used as a tracer. 2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Isotretinoin-d₅ Related Antibodies
Masse moléculaire	305.47
Formule	C₂₀H₂₃D₅O₂
Unlabeled CAS	4759-48-2
SMILES	[2H]C([2H])(C1=C(/C=C/C(C)=C/C=C/C(C)=C\C(O)=O)C(C)(C)CCC([2H])1[2H])[2H]
Livraison	Room temperature in continental US; may vary elsewhere.
Stockage	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation	Fiche technique (270 KB) Instruction de manipulation (2659 KB)
Références	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief] [2]. Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May;1(3):162-9. [Content Brief] [3]. Dahl AR, et al. Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug;6(8):3015-24 [Content Brief] [4]. Bergoli RD, et al. Isotretinoin effect on alveolar repair after exodontia--a study in rats. Oral Maxillofac Surg. 2011 Jun;15(2):85-92. [Content Brief] [5]. Ramírez-Flores PN, et al. Isotretinoin and Thalidomide Down-Regulate c-MYC Gene Expression and Modify Proteins Associated with Cancer in Hepatic Cells. Molecules. 2021 Sep 22;26(19):5742. [Content Brief]