Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives

  • Eur J Med Chem. 2009 Jun;44(6):2572-6. doi: 10.1016/j.ejmech.2009.01.029.
Bohua Long  1 ,  Shengzong Liang ,  Dingcheng Xin ,  Yingbin Yang ,  Jiannan Xiang
Affiliations
  • 1. College of Chemistry and Chemical Engineering and Biomedical Engineering Center, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China.
PMID: 19231037 DOI: 10.1016/j.ejmech.2009.01.029
Abstract

In order to improve biological behavior of the retinoyl derivatives, monoarylferrocenyl alcohols 9a and 9b were synthesized by an improved Suzuki cross-coupling method and their 13-cis-retinoic acid analogues were prepared in moderate to good yields via the Mitsunobu reaction. Their structures were confirmed by IR, (1)H NMR, (13)CNMR, MS spectra and element analysis and their antiproliferative activities were determined in vitro using human Cancer cell lines. The results of bioassay showed that these organometallic analogues exhibited higher antiproliferative activities than parent 13-cis-retinoic acid and Other retinoyl derivatives.