6429-04-5
Chemical Structure
Tetrahydropapaverine hydrochloride
- CAS. Nr.: 6429-04-5
- Formula:C20H26ClNO4
- Molecular Weight:379.88
IUPAC Name: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
InChIKey: VMPLLPIDRGXFTQ-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C=C1OC)CCNC2CC3=CC=C(OC)C(OC)=C3.[H]Cl
Biological Activity: Tetrahydropapaverine hydrochloride is a tetrahydroisoquinoline (TIQ) compound with inhibitory effects on tryptophan hydroxylase (TPH) (IC50 = 5.7 μM). Tetrahydropapaverine hydrochloride decreases intracellular serotonin content in murine mastocytoma P815 cells, with an IC50 value of 6.2 μM. Tetrahydropapaverine hydrochloride can be used for studies on potential neurotoxicity in monoaminergic neurons[1][2].
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Tetrahydropapaverine hydrochloride | 99.08% | Tetrahydropapaverine hydrochloride is a tetrahydroisoquinoline (TIQ) compound with inhibitory effects on tryptophan hydroxylase (TPH) (IC50 = 5.7 μM). Tetrahydropapaverine hydrochloride decreases intracellular serotonin content in murine mastocytoma P815 cells, with an IC50 value of 6.2 μM. Tetrahydropapaverine hydrochloride can be used for studies on potential neurotoxicity in monoaminergic neurons. | ||||||||||||||||||||
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- [1]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57. [Content Brief]
- [2]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16. [Content Brief]
Keywords
