1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. 5-HT Receptor
    Tryptophan Hydroxylase
  3. Rodatristat

Rodatristat (Synonyms: KAR5417)

Cat. No.: HY-120083
Handling Instructions

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.

For research use only. We do not sell to patients.

Rodatristat Chemical Structure

Rodatristat Chemical Structure

CAS No. : 1673568-73-4

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Description

Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice[1].

IC50 & Target

IC50: 33 nM (TPH1) and 7 nM (TPH2)[1]

In Vivo

Rodatristat (10-50 mg/kg; oral administration; mice) treatment decreases intestinal 5-HT concentrations at 50 mg/kg, their efficacy drop off significantly at the lower 10 mg/kg dose[1].

Animal Model: Mice[1]
Dosage: 10 mg/kg and 50 mg/kg
Administration: Oral administration
Result: Decreased intestinal 5-HT concentrations at 50 mg/kg, their efficacy dropped off significantly at the lower 10 mg/kg dose.
Molecular Weight

561.98

Formula

C₂₇H₂₇ClF₃N₅O₃

CAS No.

1673568-73-4

SMILES

O=C([[email protected]]1NCC2(CCN(C3=NC(N)=NC(O[[email protected]](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Rodatristat
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