1673568-73-4
Chemical Structure
Rodatristat
Synonym(s): KAR5417
- CAS No.: 1673568-73-4
- Formula:C27H27ClF3N5O3
- Molecular Weight:561.98
IUPAC Name: (S)-8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
InChIKey: ZNSPHKJFQDEABI-NZQKXSOJSA-N
SMILES: O=C([C@H]1NCC2(CCN(C3=NC(N)=NC(O[C@H](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O
Biological Activity: Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rodatristat | 98.41% | Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. | ||||||||||||||||||||
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Similarity Score 0.90
HY-101124Rodatristat ethyl -
Similarity Score 0.51
HY-13055BRTelotristat (Standard) -
Similarity Score 0.48
HY-15849ALP-533401 hydrochloride -
Similarity Score 0.47
HY-15849LP-533401 -
Similarity Score 0.47
HY-13041LX-1031 -
Similarity Score 0.46
HY-177123Refinicopan -
Similarity Score 0.45
HY-178913Tyk2-IN-23 -
Similarity Score 0.44
HY-112089Naporafenib -
Similarity Score 0.44
HY-135008J14 -
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