1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. 5-HT Receptor
    Tryptophan Hydroxylase
  3. Rodatristat ethyl

Rodatristat ethyl (Synonyms: KAR5585)

Cat. No.: HY-101124
Handling Instructions

Rodatristat ethyl (KAR5585) reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) and is also an orally active tryptophan hydroxylase 1 (TPH1) inhibitor with nanomolar in vitro potency.

For research use only. We do not sell to patients.

Rodatristat ethyl Chemical Structure

Rodatristat ethyl Chemical Structure

CAS No. : 1673571-51-1

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Description

Rodatristat ethyl (KAR5585) reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) and is also an orally active tryptophan hydroxylase 1 (TPH1) inhibitor with nanomolar in vitro potency[1][2].

IC50 & Target

5-HT[1]; TPH1[2]

In Vivo

Rodatristat ethyl (100 or 200 mg/kg; oral administration; once daily; for 28 days; male Sprague-Dawley rats) treatment decreases erum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduces pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats with monocrotaline (MCT)[1].

Animal Model: Male Sprague-Dawley rats (175-200 g)[1]
Dosage: 100 mg/kg or 200 mg/kg
Administration: Oral administration; once daily; for 28 days
Result: Decreased serum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduced pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats.
Molecular Weight

590.04

Formula

C₂₉H₃₁ClF₃N₅O₃

CAS No.

1673571-51-1

SMILES

ClC1=CC(C2=CC=CC=C2)=C([[email protected]@H](OC3=NC(N)=NC(N4CCC5(CN[[email protected]](C(OCC)=O)C5)CC4)=C3)C(F)(F)F)C=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Rodatristat ethyl
Cat. No.:
HY-101124
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