1. Metabolic Enzyme/Protease
  2. Tryptophan Hydroxylase
  3. LX-1031

LX-1031 

Cat. No.: HY-13041 Purity: 99.55%
Handling Instructions

LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

For research use only. We do not sell to patients.

LX-1031 Chemical Structure

LX-1031 Chemical Structure

CAS No. : 945976-76-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 270 In-stock
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 228 In-stock
Estimated Time of Arrival: December 31
10 mg USD 396 In-stock
Estimated Time of Arrival: December 31
25 mg USD 792 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2220 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Publications Citing Use of MCE LX-1031

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Description

LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

In Vivo

With oral administration of LX-1031 in mice, the average 5-HT reductions in the jejunum relative to control are appr 33, 51, and 66% with the 15, 45 and 135 mg/kg/day doses respectively. In a preliminary report, the effects of LX-1031, 100 mg/kg daily, on 5-HT levels in jejunal mucosa are reversible within 2 days of discontinuation in mice[1]. LX-1031 dose-dependently reduces expression of 5-HT in the duodenum, jejunum and ileum, but has no effect on brain 5-HT levels in preclinical assay[2].

Clinical Trial
Molecular Weight

538.52

Formula

C₂₈H₂₅F₃N₄O₄

CAS No.

945976-76-1

SMILES

NC1=NC(C2=CC=C(C=C2)C[[email protected]@H](C(O)=O)N)=CC(O[[email protected]](C3=CC=C(C4=CC(OC)=CC=C4)C=C3)C(F)(F)F)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (63.14 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8569 mL 9.2847 mL 18.5694 mL
5 mM 0.3714 mL 1.8569 mL 3.7139 mL
10 mM 0.1857 mL 0.9285 mL 1.8569 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.55%

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Keywords:

LX-1031LX1031LX 1031Tryptophan HydroxylaseInhibitorinhibitorinhibit

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Product name:
LX-1031
Cat. No.:
HY-13041
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