Refinicopan
Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM. Refinicopan inhibits hemolysis of rabbit red blood cells. Refinicopan can be used to study diseases mediated by complement factor D.
For research use only. We do not sell to patients.
- CAS No.: 2922808-66-8
- Formula: C29H32N2O3
- Molecular Weight:456.58
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
|
Complement factor D 10 nM (IC50) |
In Vitro
Refinicopan (Compound 001) inhibits hemolysis of rabbit red blood cells in a cell-based assay with an IC50 of 41 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 2922808-66-8
-
Molecular Weight 456.58
-
Formula C29H32N2O3
-
SMILES
NCC1=CC=CC(C2=CC(N3CCC4(CC3)CC4)=CC(COC5=C(C=CC=C5)CC(O)=O)=C2)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Refinicopan Related Classifications
HY-177123 Related Classifications
Powered by Bioz