1. Metabolic Enzyme/Protease
  2. Tryptophan Hydroxylase
  3. p-Ethynylphenylalanine

p-Ethynylphenylalanine (Synonyms: 4-Ethynyl-L-phenylalanine)

Cat. No.: HY-23460 Purity: 98.25%
Handling Instructions

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM.

For research use only. We do not sell to patients.

p-Ethynylphenylalanine Chemical Structure

p-Ethynylphenylalanine Chemical Structure

CAS No. : 278605-15-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 100 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1].

IC50 & Target

Ki: 32.6 μM (TPH)[1]

In Vitro

p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200 g)[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection
Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
Molecular Weight

189.21

Formula

C₁₁H₁₁NO₂

CAS No.

278605-15-5

SMILES

N[[email protected]@H](CC1=CC=C(C#C)C=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.4 mg/mL (23.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2851 mL 26.4257 mL 52.8513 mL
5 mM 1.0570 mL 5.2851 mL 10.5703 mL
10 mM 0.5285 mL 2.6426 mL 5.2851 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

p-Ethynylphenylalanine4-Ethynyl-L-phenylalanineTryptophan HydroxylasetryptophanhydroxylaseTPHserotonin5-HT5-HIAAInhibitorinhibitorinhibit

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Product Name:
p-Ethynylphenylalanine
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HY-23460
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