p-Ethynylphenylalanine
Based on 1 publication(s) in Google Scholar
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 278605-15-5
- Formula: C11H11NO2
- Molecular Weight:189.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) p-Ethynylphenylalanine
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Biological Activity
Ki: 32.6 μM (TPH)[1]
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (200 g)[1]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection
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Result:Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
Chemical Information
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CAS No. 278605-15-5
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Appearance Solid
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Molecular Weight 189.21
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Formula C11H11NO2
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Color Off-white to light yellow
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SMILES
N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O
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Synonyms
4-Ethynyl-L-phenylalanine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Mol Biol
Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular α-Synuclein Fibrils. [Abstract]2023 Jan 15;435(1):167716. PMID: 35792158
Solvent & Solubility
1M NaOH : 240 mg/mL (1268.41 mM; ultrasonic and adjust pH to 11 with NaOH)
1M HCl : 240 mg/mL (1268.41 mM; ultrasonic and adjust pH to 1 with HCl)
DMSO : 2.22 mg/mL (11.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1M NaOH / 1M HCl | 1 mM | 5.2850 mL | 26.4251 mL | 52.8502 mL | 132.1255 mL |
| 5 mM | 1.0570 mL | 5.2850 mL | 10.5700 mL | 26.4251 mL | |
| 10 mM | 0.5285 mL | 2.6425 mL | 5.2850 mL | 13.2126 mL | |
| 1M NaOH / 1M HCl | 15 mM | 0.3523 mL | 1.7617 mL | 3.5233 mL | 8.8084 mL |
| 20 mM | 0.2643 mL | 1.3213 mL | 2.6425 mL | 6.6063 mL | |
| 25 mM | 0.2114 mL | 1.0570 mL | 2.1140 mL | 5.2850 mL | |
| 30 mM | 0.1762 mL | 0.8808 mL | 1.7617 mL | 4.4042 mL | |
| 40 mM | 0.1321 mL | 0.6606 mL | 1.3213 mL | 3.3031 mL | |
| 50 mM | 0.1057 mL | 0.5285 mL | 1.0570 mL | 2.6425 mL | |
| 60 mM | 0.0881 mL | 0.4404 mL | 0.8808 mL | 2.2021 mL | |
| 80 mM | 0.0661 mL | 0.3303 mL | 0.6606 mL | 1.6516 mL | |
| 100 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL | 1.3213 mL |
p-Ethynylphenylalanine Related Classifications
HY-23460 Related Classifications
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