1. Metabolic Enzyme/Protease
  2. Tryptophan Hydroxylase
  3. 4-Ethynyl-L-phenylalanine

4-Ethynyl-L-phenylalanine 

Cat. No.: HY-23460
Handling Instructions

4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.

For research use only. We do not sell to patients.

4-Ethynyl-L-phenylalanine Chemical Structure

4-Ethynyl-L-phenylalanine Chemical Structure

CAS No. : 278605-15-5

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Description

4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].

IC50 & Target

Ki: 32.6 μM (TPH)[1]

In Vivo

4-Ethynyl-L-phenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
4-Ethynyl-L-phenylalanine is not inhibiting the aromatic amino acid decarboxylase[1].
4-Ethynyl-L-phenylalanine has a low affinity for various recombinant 5-HT receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200 g)[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection
Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
Molecular Weight

189.21

Formula

C₁₁H₁₁NO₂

CAS No.

278605-15-5

SMILES

N[[email protected]@H](CC1=CC=C(C#C)C=C1)C(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

4-Ethynyl-L-phenylalanineTryptophan HydroxylasetryptophanhydroxylaseTPHserotonin5-HT5-HIAAInhibitorinhibitorinhibit

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4-Ethynyl-L-phenylalanine
Cat. No.:
HY-23460
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